Dr. Ashish Mohanrao Kanhed

Assistant Professor

Specialization

Drug Design, Medicinal Chemistry and Process chemistry
M. Pharm., Ph.D.

Email Id

ashish.kanhed@nmims.edu

Phone No.

022-42332000 (Extn- 2029)

6.3 years (2.5 Years- R&D Industry; 8 months-PDF; 3.2 years-Academic).

He has obtained his PhD from The Maharaja Sayajirao University of Baroda in year 2015-16. Post PhD he has worked as Research Associate and Senior Research Associate at Navin Saxena Research and Technology Pvt. Ltd. (Research center of Rusan Pharma) in API and CADD department, where his work area was Narcotic API process development, Non-narcotic NCE design and synthesis and reaction process optimization on Continuous Flow Reactors (CFR). He also was a post-doctoral Fellow at University of Kwazulu Natal, Durban, South Africa (March to Nov. 2018) where the work area was design of novel computational models for the discovery of Hits against Tuberculosis, HIV and KSP target in Cancer treatment and their synthesis. Apart from these Dr. Kanhed has also worked as lecturer at Rahul Dharkar College of Pharmacy, Mumbai University (Duration- 1st January 2011 to 31st January 2012). He is associated with SPPSPTM, NMIMS University, Mumbai Campus since July 2019.

Interest areas:

•NCE Design and Synthesis (Alzheimer, Tuberculosis, Hypertension, HIV, and Cancer): Development of Novel Computational models for the Identification of hits
•API process development, Process optimization and process validation.

•Characterization and data interpretation of synthesized molecules using various analytical tools such as 1H NMR, 13C NMR, Mass Spectra, and HPLC etc.

•Reaction setup using Continuous Flow Reactor (CFR).

•Computer Aided Drug Design: using the computational software such as, Schrodinger, Accelrys Discovery Studio, 4D-LQTA, Derek Nexus, Pipeline Pilot, TOPKAT, BioSolveIT, Sybyl, Autodoc, Gromacs, Amber etc.

Research

•Publications –31 (International-30, National- 01)

Conferences/Workshops/Seminars attended- 25+

Academic activities

He has guided 04 M. Pharm. students for their research projects.

Awards

• Received "Shining Star Award-March, 2019” from RUSAN PHARMA for dedication and excellent performance in CFR.
• Postdoctoral fellowship from University of KwaZulu Natal, Durban, South Africa (2018).
• During PhD received Senior Research Fellowship (2014-2016) from UGC.
• During PhD received Junior Research Fellowship (2012-2014) from UGC.
• Fellowship for Master of Pharmacy from AICTE, India (2008-2010).
• Scholarship awarded by Sir Ratan Tata Trust in year 2006-07.

Professional Memberships

Registered Pharmacist at Maharashtra State Pharmacy Council.

Recent Publications:

• Kamlesh H Chavan, Nathrao Ankushrao Kedar, Ashish M Kanhed, Vishal Kumar Agrahari, Anshuman Sinha (2021). Synthesis, molecular modeling and biological evaluations of novel pyrrolidine derivatives as potential cyclooxygenase-2 (COX-2) inhibitors. Journal of the Iranian Chemical Society, https://link.springer.com/article/10.1007/s13738-020-02151-2.
• Ashish M. Kanhed, Dushyant V. Patel, Divya M. Teli, Nirav R. Patel, Mahesh T. Chhabria, Mange Ram Yadav (2021). Identification of Potential Mpro Inhibitors for the Treatment of COVID-19 by Using Systematic Virtual Screening Approach. Molecular Diversity, 25(1), 383-401.
• Ashish M. Kanhed, Dushyant V. Patel, Nirav R. Patel, Anshuman Sinha, Priyanka S. Thakor, Kishan B. Patel, Navnit K. Prajapati, Kirti V. Patel & Mange Ram Yadav (2020). Indoloquinoxaline derivatives as promising multifunctional anti-Alzheimer agents. J. Biomol. Structure and Dynamics, https://www.tandfonline.com/doi/full/10.1080/07391102.2020.1840441.
• Dushyant V Patel, Nirav R Patel, Ashish M Kanhed, Divya M Teli, Kishan B Patel, Pallav M Gandhi, Sagar P Patel, Bharat N Chaudhary, Dharti B Shah, Navnit K Prajapati, Kirti V Patel, Mange Ram Yadav (2020). Further Studies on Triazinoindoles as Potential Novel Multitarget-Directed Anti-Alzheimer’s Agents. ACS Chemical Neuroscience, 11, 3557-3574
• Dushyant V. Patel, Nirav R. Patel,Ashish M. Kanhed, Divya M. Teli, Kishan B. Patel, .Prashant D. Joshi, Sagar P. Patel, Pallav M. Gandhi, Bharat N. Chaudhary, Navnit K. Prajapati,Kirti V. Patel, Mange Ram Yadav (2020). Novel Carbazole-Stilbene Hybrids as Multifunctional anti-Alzheimer agents.Bioorganic Chemistry, 101, 103977.

• Dushyant V Patel, Nirav R Patel,Ashish M Kanhed, Sagar P Patel, Anshuman Sinha, Deep D Kansara, Annie R Mecwan, Sarvangee B Patel, Pragnesh N Upadhyay, Kishan B Patel, Dharti B Shah, Navnit K Prajapati, Prashant R Murumkar, Kirti V Patel, Mange Ram Yadav (2019) Novel Multitarget Directed Triazinoindole Derivatives as Anti-Alzheimer Agents.ACS Chemical Neuroscience, 10, 3635-3661.