LC-MS/MS INSTRUMENT LAB

SVKM’s NMIMS, SPPSPTM has installed a state-of-the-art Liquid Chromatography - Mass Spectrometry (LC-MS/MS), Shimadzu LC-MS 8040 System (Triple Quadrupole coupled with Shimadzu HPLC), which is a sophisticated, hyphenated analytical tool reaching a wide range of applications, from analysis of inorganics to biological macromolecules.

Details of the instrument housed in SVKM’s NMIMS, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management:

Model: Shimadzu LC-MS 8040

Mass range: 2 to 2000 m/z

Ionisation sources: Electrospray Ionisation (ESI) and Atmospheric Pressure Chemical Ionization (APCI)

LC: Quarternary pump HPLC with a PDA detector

Modes of analysis: Q1 Scan, Q3 Scan, Multiple reaction monitoring (MRM), Precursor Ion Scan, Product Ion Scan, Neutral Loss Scan

Research Services provided by SVKM’s NMIMS, SPPSPTM:

Molecular weight determinations of New Chemical Entities (NCEs), chemical intermediates (50-2000 daltons)
Structural determination of NCEs, unknown impurities, metabolites, degradation products, etc.
Impurity profiling of drugs, raw materials, formulations, etc.
Sensitive and accurate estimations of drugs, drug intermediates, neutraceuticals, phytopharmaceuticals, different type of formulations, cosmetic products, etc.
Analytical method development and validation with application of method to samples to meet regulatory requirements
Bioanalytical method development and validation with application of method to samples to meet regulatory requirements
Preclinical and clinical pharmacokinetic analysis of drugs, drug intermediates, different type of formulations, cosmetic products, etc.
Drug metabolism studies – Metabolite identification, Phase I and II metabolic profiling, drug-drug interactions, drug-phytocostituents, drug-food interactions, etc.
Efficacy and toxicity profiling of NCEs, environmental chemicals, herbal products, etc.
Phytochemical investigations
Fingerprinting of herbal medicines
Biomarker analysis for disease profiling
Therapeutic drug monitoring (TDM) and related applications

Advantages of LC-MS/MS:

High sensitivity (pg/ml)
High selectivity
Multi-component simultaneous analysis
Accurate qualitative analysis (structural elucidation – molecular mass, fragmentation, etc.)
Accurate quantitative analysis (Analytical and Bio-analytical samples)

Main objectives of LC-MS/MS:

Improve research output of the university by application of this technique to all fields of research (life and material sciences)
To provide best research facilities to students and faculties of other universities and colleges, scientists and researchers from pharmaceutical, food, cosmetics, herbal, environmental and pesticide industries
To provide hands-on-training workshop to students, faculties and industry personnel
Develop new research methodologies

Sample Request Form

Research and analytical charges

For any queries regarding services provided please contact us at sppsptm@nmims.edu (cc to mahesh.palkar@nmims.edu)