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LCMS

LC-MS/MS Instrument Lab

Liquid chromatography - mass spectrometry (LC-MS/MS)

SVKM’s NMIMS, SPPSPTM has installed a state-of-the-art Liquid Chromatography - Mass Spectrometry (LC-MS/MS), Shimadzu LC-MS 8040 System (Triple Quadrupole coupled with Shimadzu HPLC), which is a sophisticated, hyphenated analytical tool reaching a wide range of applications, from analysis of inorganics to biological macromolecules.

Details of the instrument housed in SVKM’s NMIMS, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management:

Model: Shimadzu LC-MS 8040

Mass range: 2 to 2000 m/z

Ionisation sources: Electrospray Ionisation (ESI) and Atmospheric Pressure Chemical Ionization (APCI)

LC: Quarternary pump HPLC with a PDA detector

Modes of analysis: Q1 Scan, Q3 Scan, Multiple reaction monitoring (MRM), Precursor Ion Scan, Product Ion Scan, Neutral Loss Scan

Research Services provided by SVKM’s NMIMS, SPPSPTM:

  • Molecular weight determinations of New Chemical Entities (NCEs), chemical intermediates (50-2000 daltons)
  • Structural determination of NCEs, unknown impurities, metabolites, degradation products, etc.
  • Impurity profiling of drugs, raw materials, formulations, etc.
  • Sensitive and accurate estimations of drugs, drug intermediates, neutraceuticals, phytopharmaceuticals, different type of formulations, cosmetic products, etc.
  • Analytical method development and validation with application of method to samples to meet regulatory requirements
  • Bioanalytical method development and validation with application of method to samples to meet regulatory requirements
  • Preclinical and clinical pharmacokinetic analysis of drugs, drug intermediates, different type of formulations, cosmetic products, etc.
  • Drug metabolism studies – Metabolite identification, Phase I and II metabolic profiling, drug-drug interactions, drug-phytocostituents, drug-food interactions, etc.
  • Efficacy and toxicity profiling of NCEs, environmental chemicals, herbal products, etc.
  • Phytochemical investigations
  • Fingerprinting of herbal medicines
  • Biomarker analysis for disease profiling
  • Therapeutic drug monitoring (TDM) and related applications

Advantages of LC-MS/MS:

  • High sensitivity (pg/ml)
  • High selectivity
  • Multi-component simultaneous analysis
  • Accurate qualitative analysis (structural elucidation – molecular mass, fragmentation, etc.)
  • Accurate quantitative analysis (Analytical and Bio-analytical samples)

Main objectives of LC-MS/MS:

  • Improve research output of the university by application of this technique to all fields of research (life and material sciences)
  • To provide best research facilities to students and faculties of other universities and colleges, scientists and researchers from pharmaceutical, food, cosmetics, herbal, environmental and pesticide industries
  • To provide hands-on-training workshop to students, faculties and industry personnel
  • Develop new research methodologies

Sample Request Form

Research and analytical charges

For any queries regarding services provided please contact us at sppsptm@nmims.edu (cc to Amisha.vora@nimims.edu / Kapil.juvale@nmims.edu) or on 022-42332000/42332010

ANNOUNCEMENT

Admissions open for M. Pharm. / M. Pharm.+MBA and Ph. D. (Pharm Sciences)NPAT for B. Pharm + MBA (Pharma. Tech.) courseOne Week Faculty Development Program on Applications and Impact of Novel Tools in Pharma ResearchLC-MS/MS facility at the SPPSPTMReport on International Conference on Artificial Intelligence in Health Care (IC. AIHC)

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