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Research

Research which is multi-disciplinary and Industry oriented is a priority area at SPP-School of Pharmacy & Technology Management

Some of the emerging areas having commercial value are identified as high priority for research at SPPSPTM. These areas are:

  1. Stem cell, their characterization, and their use as regenerative medicine

  2. Pharmacological evaluation of small molecules/plant constituents/natural products in various animal disease models (Myocardial Infarction,Diabetes Type I & II, Hypertension, Hypercholesterolemia, Atherosclerosis and Gastric Ulcer)

  3. Role of bioenhancers in improving the clinical efficacy of some drugs

  4. Importance of reduction of drug-protein binding

  5. Industrial effluent treatment and recycling of water

  6. Use of nanotechnology in developing novel drug deliveries

  7. Research in oncology, chemotherapy and opportunistic infections

  8. Medicated stents/drug-eluting stents

  9. Chiral separation (Dynamic Kinetic Resolution)

  10. Discovery of novel agents including use of Computer-aided Drug Designing

  11. Toxicological studies for Pharma Industries

  12. Cryogenic extraction of active constituents from plants

  13. Memory enhancers of plant origin

  14. Preparation of Pharmacopoeia monograph

  15. IPRS for API and other related substances thereof

  16. Wuster film coating and drug layering

  17. Oral nanoparticles and oral liquid/solid dosage form

  18. Nanoparticles in cosmetics

Apart from these our students and faculty are working in areas like NDDS projects, Impurity profiling, Analytical Method Development and Validation,development of herbal anti – diabetic formulations, toxicity studies and pre clinical studies for their post graduate and Ph.D studies and Research activities.

Projects in the following areas are currently being carried out at the school

PHARMACEUTICAL ANALYSIS

  1. Analytical method development and validation

  2. Method development for bioavailability/ bioequivalence studies

  3. Impurity profiling

  4. Chiral chromatography

  5. Study on immobilization of enzymes

  6. Spectroscopic analysis using UV and IR.

  7. HPLC, GC and HPTLC analysis.

PHYTOCHEMISTRY

  • Bioactivity guided fractionation of herbal extracts, isolation of active constituents and its structural elucidation

  • Identification and authentification of herbal drugs

  • Standardization of herbal extracts

PHARMACOLOGY AND TOXICOLOGY

  • Pharmacological & molecular studies on cardioprotective activity of natural products, herbal active constituents and small molecules in in vitro and in vivo models of myocardial infarction

  • Pharmacological evaluation of natural products, herbal active constituents and small molecules in various animal disease models (Diabetes Type I & II, Hypertension, Hypercholesterolemia, Atherosclerosis and Gastric Ulcer)

COMPUTER AIDED DRUG DESIGN

  • Structure based drug design

  • Virtual screening

SYNTHETIC CHEMISTRY

  • Process development of bulk drugs and drug intermediates

  • Synthesis of impurities and metabolites of drugs

  • Lead optimization studies

  • Microwave assisted synthesis of compounds

  • Biochemical synthesis

  • Resolution of drugs (chemical and enzymatic)

DRUG METABOLISM AND PHARMACOKINETIC STUDIES

  • Phenotype study

  • In vitro pharmacokinetic study

FORMULATION AND DEVELOPMENT

  • Preformulation studies

  • Design and evaluation of formulations

  • Tablets-Effervescent, Immediate release, Sugar coated, Bilayer, Enteric coated, Film coated, Extended release.

  • Capsules

  • Liquid orals

  • Ointments

  • Gels

  • Powders

  • Injectables

  • Controlled release drug delivery systems by hydrophilic single matrix tablet

  • Sustained release formulations using matrix and coating technology

  • Orally disintegrating tablets and its taste masking

  • Design and formulation of highly insoluble drugs by changing its polymorphic form.

  • Development of Geomatrix technology for tabletting.

  • Taste masking of drugs

  • Scale up & Technology transfer to production shop floor of the formulated products.

  • In-vitro and in-vivo evaluation of the formulations

NOVEL DRUG DELIVERY SYSTEMS

Design and Development of novel drug delivery systems such as

  • Ophthalmic drug delivery system

  • Bioadhesive drug delivery system

  • Osmotic drug delivery system

  • Liposomal drug delivery system

  • Ethosomes drug delivery system

  • Transdermal drug delivery

  • Hydrogel based oral drug delivery systems

OTHER ACTIVITIES SUPPORTING INDUSTRY:

INTELLECTUAL PROPERTY RIGHTS

Patent search and IPR related issues

REGULATORY AFFAIRS

  • Preparation of Standard Operating Procedures (SOPs)

  • Preparation of Common Technical Document (CTD) for API/formulation

  • Carrying out technical audit

  • Training of personnel for overseas audit.

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