Dr. Sinjini Sarkar

Qualification              : M. Pharm., Ph.D.

Specialization             : Pharmacology

E mail                         : sinjini.sarkar@nmims.edu

Phone                         : 022-42332000 (Extn- 2013)

Experience                 : 6 years

(Research – 4+ years, Academics-2 years)

Dr. Sinjini Sarkar holds a Ph.D. from Chittaranjan National Cancer Institute, Kolkata, and Jadavpur University, Kolkata. Her research involves identification of novel genetic mutations and protein expressions in advanced ovarian carcinoma, contributing valuable insights into potential biomarkers for clinical efficacy and associated toxicity. Her work on chemotherapy outcomes and quality of life assessments for Indian women with ovarian carcinoma has garnered recognition through publication in prestigious international peer-reviewed journals and presentations at global conferences. She has significant experience in small animal models of emphysema and hepatocellular carcinoma. As a former full-time Assistant Professor at the School of Pharmacy, Techno India University, West Bengal, she taught subjects such as Pharmacology, Biostatistics, Research Methodology, and Computer-Aided Drug Delivery Systems to B. Pharm and M. Pharm students. Her role also extended to serving as placement coordinator there, reflecting her commitment to both academic excellence and practical application in the field of pharmaceutical sciences.

Interest areas:

• Molecular Pharmacology
• Identifying Biomarkers for cancer treatment
• Treatment of Cancer-related Cachexia
• Identifying novel treatment for Chemotherapy-induced Neuropathic Pain (CIPN)

Research

• Publications – 11 (International-10 , National- 01)
• Book Chapters- 01
• Roy Pradhan, S., Mahata, S., Ghosh, D., Kumar Sahoo, P., Sarkar, S., Pal, R., & D. Nasare, V. (2020). Human Papillomavirus Infections in Pregnant Women and Its Impact on Pregnancy Outcomes: Possible Mechanism of Self-Clearance. IntechOpen. doi: 10.5772/intechopen.90197
• Presentations- Total number (International- 02, National- 02)
• Government funded projects – 01
  • Completed (Study on MAD and BUB1 genes of spindle assembly checkpoint with response to primary adjuvant chemotherapy in advanced epithelial ovarian cancer, Department of Health Research, MoHFW, GoI, amount in Rs. 32,00,000/-Study site: Chittaranjan National Cancer Institute, Kolkata)

Conferences/Workshops/Seminars attended: 10

• Poster presentation: Sinjini Sarkar; Pranab Kumar Sahoo; Sutapa Mahata; Ranita Pal; Sushmita Ghosh; Tanmoy Bera; Vilas D. Nasare., MAD1L1 and MAD2L2 polymorphism in advanced ovarian carcinoma patients and its clinical impact, presented at FIGO XXIII World Congress of Gynaecology and Obstetrics held on 21-28th Oct, 2021. Abstract published: Int J Gynecol Obstet. 2021; 155(Suppl. 2):127–532. DOI: 10.1002/ijgo.13886 (IF: 4.4)
• Poster presentation: Sarkar, P.K. Sahoo, T. Mistry, R. Pal, S. Ghosh, T. Choudhury, S. Mahata, M. Vernekar, T. Bera, K.K. Mukherjee, P. Nath, V.D. Nasare, BUB1 (2530C>T) polymorphism and expression affects chemotherapy response and predicts poor prognosis in advanced epithelial ovarian cancer, presented at ESMO Asia Congress held on 2-4th December, 2022. Abstract published: Annals of Oncology 2022; 33(Suppl. 9): S1508-S1509. DOI: https://doi.org/10.1016/j.annonc.2022.10.223 (IF: 51.769)
• Oral presentation: Sinjini Sarkar, Pranab Kumar Sahoo, Sushmita Ghosh, Sutapa Mahata, Ranita Pal, Tanuma Mistry, Trisha Choudhury, Manisha Vernekar, Puja Chatterjee, Partha Nath, Kalyan K Mukherjee, Vilas D Nasare. Clinical outcomes of paclitaxel-carboplatin chemotherapy with impact of mitotic checkpoint proteins in advanced ovarian cancer patients, presented at 5th International Conference on Nutraceuticals for Cancer and Other Chronic Disease (2022) Organized by Department of Zoology, University of Delhi, October 7-9,2022, IL-8 Page 48.
• Poster presentation: Sahoo, P. K., Sarkar, S., Mahata, S., Pal, R., Mistry, T., Ghosh, S., Choudhury, T., Bhowmick, A. K., Mukherjee, K. K., Datta, S., & Nasare,V. D. (2022). Clinical Efficacy and Quality of Life of Oral Cancer Patients Treated with Paclitaxel/Cisplatin/5-FU Vs Paclitaxel/Carboplatin Chemotherapeutic Regimens in a Tertiary Cancer Center in Eastern India, Journal of the National Comprehensive Cancer Network, 20(3.5), CLO22-081-CLO22-081. Retrieved Apr 7, 2022 (IF: 12.693)
• Poster presentation: Third prize winner, at National workshop on ‘Pharmacists for Healthy India’ organized by IPA, Bengal Branch and Jadavpur University on 27^th Nov, 2016. Topic of Poster: ‘Interference of autophagy in regulation of cytokine production: Influence on defense against microorganisms.’
• Attended the 2-days IIT Bombay BioPharma Summit, 2023 on 23^rd and 24^th Nov, 2023.
• Completed a 5-day Foundation Course in Clinical Research conducted by Tata Consultancy services at TCS, Thane for a Academia Industry Programme, in August, 2023.
• Participated in the Pre-conference Workshop on ‘Clinical Drug Research, Good Clinical Practice and Ethics’ at the 27^th Annual Conference, Indian Pharmacological Society, WB on 7^th Feb, 2018.
• Participated in the Pre-conference Workshop on ‘Adverse Drug Reaction Monitoring and Safe Therapy’ at Annual State Conference of Indian Pharmacological Society, WB on 17th Feb, 2016.
• Attended seminar on ‘Facets of Insilico Chemical Biology for Novel Therapeutics’ held at CSIR-IICB, Kolkata, on 18th June, 2013.

Academic activities

• Appointed as External referee conducting Viva-Voce examinations of B. Pharm (Pharmacology and Human Anatomy & Physiology) students from The Neotia University and NSHM College of Pharmaceutical Technology.
• Guest lecturer appointed by Pfizer for Pharmacy engagement programme in Mumbai location for pharmacists working at Breach Candy hospital, Mumbai in October 2023.
• Worked as an immediate supervisor for M.Sc (3) and B.Tech (2) students from University of Calcutta and KIIT, Bhubaneshwar for their 3-6 months dissertation.

Awards

• Awarded Young Scientist Fellowship (2018) from Department of Health Research, MoHFW, GoI
• Awarded College Topper, M. Pharm (2017), NSHM College of Pharmaceutical Technology, Kolkata
• Qualified Graduate Pharmacy Aptitude Test (2016)

Professional Memberships

• Registered Pharmacist, West Bengal State Pharmacy Council
• Member, Cochrane

Recent Publications

1. Sarkar S, Sahoo PK, Mahata S, Pal R, Ghosh D, Mistry T, Ghosh S, Bera T, Nasare VD. Mitotic checkpoint defects: en route to cancer and drug resistance. Chromosome Res. 2021 Jun;29(2):131-144. doi: 10.1007/s10577-020- 09646-x. Epub 2021 Jan PMID:33409811. (IF-4.62)
2. Sarkar S, Pal R, Mahata S, Sahoo PK, Ghosh S, Chatterjee P, Vernekar M, Mandal S, Bera T, Nasare VD. Evaluation of numerical rating scale and neuropathic pain symptom inventory pain scores in advanced ovarian carcinoma patients undergoing surgery and first-line chemotherapy. J Clin Transl Res. 2022 Jan 25;8(1):54-60. PMID: 35187290; PMCID: (IF-2.938)
3. Mahata S, Behera SK, Kumar S, Sahoo PK, Sarkar S, Fazil MHUT, Nasare VD. In-silico and in-vitro investigation of STAT3-PIM1 heterodimeric complex: Its mechanism and inhibition by curcumin for cancer therapeutics. Int J Biol 2022 May 31; 208:356-366. Doi: 10.1016/j.ijbiomac.2022.03.137. Epub 2022 Mar 26. PMID: 35346675. (IF: 8.025)
4. Mahata S, Sahoo PK, Pal R, Sarkar S, Mistry T, Ghosh S, Nasare VD. PIM1/STAT3 axis: a potential co-targeted therapeutic approach in triple-negative breast cancer. Med Oncol. 2022 May 15;39(5):74. Doi: 10.1007/s12032- 022-01675-2. PMID: (IF: 3.738)
5. Sahoo PK, Sarkar S, Ghosh D, Mahata S, Pal R, Mistry T, Ghosh S, Roy A, Bucha H, Mandal S, Nasare VD. Premalignant and malignant lesions of oral cavity in eastern India: a hospital-based study. Eur J Cancer Prev. 2020 Nov (IF: 3.031)
6. Sarkar S, Ghosh D, Mahata S, Sahoo PK, Roy A, Vernekar M, Datta K, Mandal S, Nasare VD. Sociodemographic factors and clinical presentation of women attending Cancer Detection Centre, Kolkata for breast examination. J Clin Transl 2020 Mar 19;5(3):132-139. PMID: 32617427; PMCID: PMC7326264 (IF:2.938)
7. Ghosh, D., Mahata, S., Sahoo, P.K., Sarkar, S., Roy, A., Datta, K., Vernekar, M., Mandal, S., & Nasare, V.D. (2019). Socio-demographic Characteristics and Use of Pap Smear for Cervical Cancer Screening among Women of Eastern Part of Indian Journal of Gynecologic Oncology, 17. (IF:0.25)
8. Sarkar S. (2019). Short-term treatment of elastase-LPS induced exacerbation model of emphysema in mice with docosahexaenoic acid, a precursor of anti-inflammatory Int J Pharm Sci & Res; 10(4): 1775-83.
9. Mistry T, Nath A, Pal R, Ghosh S, Mahata S, Kumar Sahoo P, Sarkar S, Choudhury T, Nath P, Alam N, Nasare VD. Emerging Futuristic Targeted Therapeutics: A Comprising Study Towards a New Era for the Management of TNBC. Am J Clin Oncol. 2023 Dec 19. doi: 10.1097/COC.0000000000001071. Epub ahead of print. PMID: 38145412.
10. Sarkar S, Sahoo PK, Pal R, Mistry T, Mahata S, Chatterjee P, Vernekar M, Mandal S, Bera T, Nasare VD. Assessment of quality of life among advanced ovarian cancer patients in a tertiary care hospital in India. Support Care Cancer. 2022 Apr;30(4):3371-3378. doi: 10.1007/s00520-021-06735-3. Epub 2022 Jan 6. PMID: 34988703. (IF-3.359).
11. Sahoo PK, Bhowmick AK, Sarkar S, Mahata S, Pal R, Mistry T, et al. Outcomes of 3 year follow up with induction vs first line chemotherapy in oral cancer patients: An observational hospital based study. J Can Res Ther 2023; XX:XX XX.