Dr. Mahesh B. Palkar

Qualification              : M. Pharm., Ph.D., Post-Doc

Specialization            : Pharmaceutical and Medicinal Chemistry

E mail                           : mahesh.palkar@nmims.edu

Phone                          : 022-42332000 (Extn - 2080)

Experience                 : 23 years (Academics);

During the tenure of 23 years, Dr. Mahesh Palkar, served mainly in K.L.E. Society’s Pharmacy Institutions at different capacities like Professor, and Principal during which major administrative responsibilities like NBA, NIRF, NAAC & PCI were successfully accomplished in addition to his routine academic & research portfolios. Till date, he has successfully guided 17 M.Pharm projects and co-guided 3 Ph.D candidates, and presently he is guiding 2 Ph.D. scholars. He has successfully completed Post-Doctoral Research Fellowship (PDF) at the College of Health Sciences, University of KwaZulu-Natal, Durban (South Africa). He has published > 65 research articles in peer-reviewed national/ international journals with a cumulative impact factor of > 170 and his Scopus author h index is 23. Further, he has authored or published 7 Indian patents. He has received research grants of worth Rs.30 lakhs from various funding agencies. He has worked as Organizing Secretary in organizing various state level conferences/ workshops.

Interest areas:

• Rational drug design and development [CADD and Molecular Modelling]
• Synthesis various bioactive heterocyclic compounds from Synthetic/Semi-synthetic/Natural leads
• Drug-drug and/or drug-excipient interaction studies
• Anti-cancer and anti-tubercular drug development
• Analytical method development

Research

• Publications – 65 (International – 48, National – 17)
• Author h-index: 22 (Scopus); 23 (Google Scholar); 20 (Web of Science)
• Total citations: 1215 (Scopus); 1762 (Google Scholar); 1135 (Web of Science)
• Books- Nil
• Book Chapters- 02 (Accepted)
• Patents- 08 (Granted – 6, Published – 2)
• Presentations- 17 (International – 09, National – 08)
• Government funded projects – 02
  • Design, synthesis and evaluation of in-vitro enzyme inhibition assay of novel anti-tubercular agents, Research Promotion Scheme (RPS) of AICTE, New Delhi, Rs.14.8 lakhs
  • Design, Synthesis, and Biological Evaluation of DNA gyrase inhibitors as Antimicrobial and Anti-tubercular Agents, University of KwaZulu-Natal of South Africa, Rs.15.6 lakhs
• Industry projects – Nil

Conferences/Workshops/Seminars attended – 60 (Attended as delegate – 30; Attended as resource person – 22; Worked as Organizing secretary/member – 06; Attended as Co-chairman in Scientific Sessions – 02).

Academic activities

• He has guided 17 no. of M.Pharm. students for their research projects.
• He has co-guided 03 no. of PhD candidates successfully and 02 no. of Ph.D. scholars are registered under his supervision. 

 Awards/Honors/Recognitions

• Received ‘First Prize’ for the oral presentation of research work entitled "Discovery of novel carbohydrazide hybrids of Isatin–Bromopyrrole frameworks as potential mycobacterial DNA gyrase inhibitors: An In-vitro and In-silico Evaluation”, at ANRF & DBT sponsored International Research Conference "Pharmanecia 4.E”, jointly organized by Operant Pharmacy Federation and JSS College of Pharmacy, Ooty (Tamilnadu) held on 7th & 8th March 2025
• Recognized as Co-chairperson and Poster Evaluator for a scientific session at SERB, DST, Govt. of India sponsored national conference on "Nanomedicine and Artificial Intelligence: Past, Present and Future” held at SVKM’s NMIMS, School of Pharmacy & Technology Management, Shirpur, Maharashtra, on 23^rd and 24^th July 2022.
• Received ‘Best Teacher Award’ on eve of Teachers Day-2015 from L.E. University, Belagavi, on 5^th September 2015.
• Co-chaired a scientific session (Poster) at 1^st Annual Convention of Karnataka State APTI (KAAPTICON-2015) held at BLDEA’s College of Pharmacy, Vijaypur-586103, Karnataka, on 28^th and 29^th March 2015.
• Received Post-Doctoral Research Fellowship (PDRF) from College of Health Sciences, University of KwaZulu-Natal (UKZN), Westville Campus, Durban (South Africa) for the period of one (1) year from 27^th Aug 2013 to 25^th August 2014.
• Received a research grant of worth 14.8 Lakhs and Worked as Principal Co-Investigator under Research Promotion Scheme (RPS) project entitled "Design, synthesis and Evaluation of in-vitro enzyme inhibition assay of novel anti-tubercular agents” sponsored by AICTE, New Delhi (From: April 2009 to March 2012).
• Recipient of Travel Grant of worth 35,000 for presenting a Research Paper at EURO-QSAR-2004 held at Istanbul (Turkey).
• Secured 5^th rank to Rajiv Gandhi University of Health Sciences, Karnataka, Bangalore, in post-graduation (M. Pharm.)
• Qualified in All-India competitive exam Graduate Aptitude Test in Engineering (GATE) conducted by IIT Kharagpur – March 1999.
• Recipient of silver medal for securing 2^nd rank in B. Pharm. Course from Karnataka University, Dharwad.

Professional Memberships

• Registered Pharmacist, Karnataka State Pharmacy Council (KSPC).
• Life Member of the Association of Pharmaceutical Teachers of India (APTI).
• Expert Member, Board of Studies, Shree Dhanawantry Pharmacy College, Kim, Surat
• Member of MCOPS Alumni Association, Manipal University, Karnataka

Recent Publications

• Bhamare UU, Patil TS, Chaudhari DP, Palkar MB. Emerging Versatile Role of Carbon Quantum Dots in Theranostics Applications for Breast Cancer Management. ChemNanoMat. 2025, 11(6), https://doi.org/10.1002/cnma.202500030 [Impact factor: 2.6] [Citation: 01]
• Bhamare UU, Patil VK, Chaudhari CJ, Patel GM, Palkar MB. Exploring the emerging technological expansions of MXenes-based nanomaterials: a comprehensive review. Composite Interfaces, 2025, 1–57. https://doi.org/10.1080/09276440.2025.2489819 [Impact factor: 2.1] [Citation: 01]
• Mahapatra C, Gawad J, Bonde C, Palkar MB. Bioelectric Membrane Potential and Breast Cancer: Advances in Neuroreceptor Pharmacology for Targeted Therapeutic Strategies. 2025, 4(2), 9-27. https://doi.org/10.3390/receptors4020009
• Dahiya K, Palkar MB, Sharma S. Unlocking the Potential of THR-β Agonist Therapies: Resmetirom’s Chemistry, Biology, and Patent Insights. Naunyn-Schmiedeberg’s Archives of Pharmacology. 2025, 1-18, https://doi.org/10.1007/s00210-025-03880-y [Impact factor: 3.1] [Citation: 01]
• Kadam R, Palkar MB, Pingili RB. Mechanisms involved in the valproic acid-induced hepatotoxicity: a comprehensive review. Toxicology Mechanisms and Methods. 2025, 1-16 https://doi.org/10.1080/15376516.2025.2459176 [Impact factor: 3.2] [Citation: 00]
• Gawad J, Bonde C, Bonde S, Sharma M, Suthar D, Palkar MB, Beldar V, Dhokchawle B, Raghuwanshi V. Investigating the Impact of Acute and 28-days Oral Exposure to Decaprenyl phosphoryl-β-D-ribose 2’- epimerase (DprE1) Inhibitors on Vital Organ Function in Swiss Albino Mice. J. Pharm. Edu. Res., 2025; 59 (1s): s151-s158. https://DOI:10.5530/ijper.20256810 [Impact factor: 0.8]
• Bhadane K, Patil B, Chinnam S, Das B, Patil C, Gawli C, Ahmad I, Shimpi A, Agrawal Y, Patil A, Shirkhedkar A, Rai N, Palkar MB, Ansari SK, Ansari IA, Kundu CN, Patel H. Synthesis, impurity profiling, simultaneous NP-HPTLC method development, molecular modelling study and EGFR tyrosine kinase inhibitory profile: An integrated approach to characterize desethynyl erlotinib process impurity. Analytical Chemistry Letters, 2025, 15(1), 1–18. https://doi.org/10.1080/22297928.2024.2441995 [Impact factor: 1.0]
• Jain P, Noolvi MN, More U, Palkar MB. Molecular docking & amp; MD simulation studies to design benzothiazole-thiazole hybrids as potent p56lck inhibitors for the treatment of cancer. Bio interface Research in Applied Chemistry. 2024, 14(6), 144-163. https://doi.org/10.33263/BRIAC146.144. [Impact factor: Nil] [Citation: 00]
• Bagratee T, Prawlall R, Ndlovu T, Sibisi S, Ndadane S, Shaik BB, Palkar MB, Gampa R, Karpoormath R. Exploring the Recent Pioneering Developments of Small Molecules in Antimalarial Drug Armamentarium: A Chemistry Prospective Appraisal. Chemistry and Biodiversity. 2024, 21(8), e202400460. https://doi.org/10.1002/cbdv.202400460 [Impact factor: 2.3] [Citation: 00]
• Jaber T, More UA, Sidat P , Khan S, Jain P, Noolvi MN, Palkar MB, Design, synthesis and evaluation of novel coumarin-oxa/thiadiazole hybrids as AchE inhibitors for the treatment of alzheimer’s disease. Indian Journal of Chemical Technology. 2024, 31 (3), 483-493. https://doi.org/56042/ijct.v31i3.3786 [Impact factor: 0.76] [Citation: 00]
• Mahajan P, Palkar MB, Pingili RB. Drug reactive metabolite-induced hepatotoxicity: a comprehensive review. Toxicology Mechanisms and Methods. 2024, 34(5) 1–21. https://doi.org/10.1080/15376516.2024. 2332613 [Impact factor: 3.2] [Citation: 00]
• Bhirud D, Agrawal G, Shah H, Patel A, Palkar MB, Bhattacharya S, Prajapati BG, Nitrosamine Impurities in Pharmaceuticals: An Empirical Review of their Detection, Mechanisms, and Regulatory Approaches. Current Topics in Medicinal Chemistry. 2024, 24 (6), 503-522. DoI:10.2174/01156802662786362 40125113509. [Impact factor: 3.4] [Citation: 00]
• Reddy SM, Mokoena S, Obakachi VA, Shaik BB, Kushawaha B, Kushwaha ND, Ike BW, Palkar MB, Bonde CG, Ganai AM, Chauhan R, Kajee A, Ghai M, Kidwai S, Singh R, Karpoormath R. Novel N-Phenyl 4,5-Dibromo Pyrrole Hybrids as Promising DNA Gyrase Inhibitors: Design, Synthesis and Antimicrobial Evaluation. Journal of Molecular Structure 2024, 1302, 137359. [Impact factor: 3.841] [Citation: 00]
• Ganai AM, Pathan TK, Mohite SB, Voj´aˇckov´a V, ˇRezníˇckov´a E, Kozlansk´a K, Kryˇstof V, Govender K, Mokoena S, Merugu SR, Palkar MB, Moodley K, Karpoormath R. Design and synthesis of novel 1,2,4-triazolo[4,3-b] pyridazine derivatives with anti-cancer activity. Journal of Molecular Structure 2023, 1291, 135938 https://doi.org/10.1016/j.molstruc.2023.135938 [Impact factor: 3.841] [Citation: 00]