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Dr. Vaishali Londhe

Dr. Vaishali Londhe

Professor, Section Head, Department of Pharmaceutics
M. Pharm., Ph.D

Specialization

Pharmaceutics

Email Id

vaishali.Londhe@nmims.edu

Phone No.

+91-022-42332000 (Extn- 2030)

She has worked in Sun Pharmaceutical Advanced Research Centre, Mumbai and Aurobindo Pharmaceutical Limited Research centre, Mumbai at various levels. This work includes mainly analytical method development, dissolution method development, impurity profiling, analytical method validation for ANDA projects and documentation.

In academics, she is teaching under graduates, post graduate students and guiding students for research activities. In academics, working on liposomes, nanoparticles, microneedles, solubility enhancement for bioavailability enhancement, use of DOE, bioanalytical method development and validation.

Interest areas:

  • Novel drug delivery systems like nanoparticles, liposomes, microneedles
  • Solubility enhancement methods like solid dispersions, inclusion complexation, SMEDDS, cocrystals for improvement in bioavailability
  • Modified oral delivery like ODT, oral jelly etc. using Design of Experiments (DOE)
  • Transdermal drug delivery
  • Analytical/ bioanalytical method development and validation, impurity profiling
  • Herbal formulation development

Research

  • Publications –    56 (International- 51, National-05)
  • Book Chapters –01
  • Patents : 2 (Indian, granted)
  • Vaishali Y. Londhe, Shailesh Sharad Kulkarni, Dr. Shailesh Singh, IN378867 titled ‘Oral semisolid formulations of metformin in extended release form’, Date of filing 10/09/2019
  • Amisha Kamlesh Vora, Vaishali Yogesh Londhe, Nancy S. Pandita, IN382958 titled ‘A novel and stable composition of punicalagins’, Date of filing 14/01/2015
  • Presentations –   (International-02, National-)
  • Government funded projects – 01 (ongoing)
  • DST SERB Core research grant titled ‘Microneedles: can be a good option for antipsychotic drug delivery? (CRG/2018/003176) of Rs 3083360/-  (ongoing)
  • Industry projects  04
  • To Prepare orally disintegrating film by Nagasse India Pvt Ltd, rs 1,00,000/- (ongoing)
  • Formulation and evaluation capsules containing solubilized Febuxostat for bioavailability enhancement – Rs. 25,000 by ACG Capsules (ongoing)
  • Dermatopharmacokinetic studies of Derma Products by Ajanta Pharma Ltd – Rs 47,200/- (Completed)
  • Analytical Method development and validation for Assay and related substances of Isotretinoin liposomal gel by IPCA Laboratories Ltd – Rs. 1.5 Lakh (completed)

Conferences/Workshops/Seminars attended – 20

Academic activities

  • 6 students successfully completed Ph D under her guidance.
  • 4 students are registered for Ph D under her supervision.
  • M Pharm - 90 students inclusive of Major, minor and part-time (including 1 Industry sponsored in- house project for Part time).

 Awards

  • DST International Travel Scheme (ITS) of Rs 62700/- to attend and to participate in "46th Controlled Release Society Annual meeting and Exposition, Spain (21 July, 2019 to 24 July, 2019)
  • DST SERB Core Research Grant grant (CRG/2018/003176) of Rs 3083360 for project ‘Microneedles: can be a good option for antipsychotic drug delivery?’
  • DST Travel grant (Rs 92,036/-) and NMIMS grant (Rs 50,000/-) to present posters at AAPS 2012 Annual Conference and Exhibition held on 14-18th October 2012 at Chicago IL
  • 3rd Prize to Mr. Divyen Shah for Best Poster  on ‘Nanotechnology approach for immunomodulatory drug’ in 'Two day National Conference on Particle Technology with Special Emphasis on Nanotechnology'  held on 22nd-23rd April 2011
  • 3rd Prize to Miss Sneha Ranade for Best  Poster  on ’FORMULATION AND EVALUATION OF FAST DISSOLVING FILM OF TELMISARTAN’ in  Manshodhan II, Category A,  organized by Mithibhai College on 26th November 2011
  • AICTE scholarship (For Ph. D., Academic years 1996 – 1999)
  • AICTE scholarship (For M. Pharm., Academic years 1994 – 1996)

Professional Memberships

  • Life Member of Indian Pharmaceutical Association (IPA)
  • Life Member of Association of Pharmaceutical Teachers of India (APTI)
  • Life Member of Society of Pharmaceutical Education & Research (SPER)
  • Registered Pharmacist under Maharashtra State Pharmacy Council of India.

 

Key Publications

  • Akshayya Pawar, Vaishali Y. Londhe, Rupali S. Bhadale, "Formulation and Characterization of Sublingual Tablets of Iloperidone Prepared by Microenvironmental pH Regulated Approach” October 2020, Journal of Pharmaceutical Innovation; DOI: 10.1007/s12247-020-09502-9 (Impact Factor: 1.692)
  • Vaishali Y. Londhe, Akshayya Pawar, Harish Kundaikar, Studies on spectral characterization and solubility of hydroxypropyl β-cyclodextrin/iloperidone binary and ternary complexes using different auxiliary agents, Journal of Molecular Structure, Volume 1220, 15 November 2020, 128615(Impact factor 2.1)
  • Vaishali Londhe and Bhavya Bhasin, Transdermal lipid vesicular delivery of iloperidone: formulation, in vitro and in vivo evaluation, Colloids and surfaces B: Biointerfaces,  July 2019, 110409 (impact factor 3.997)
  • M Paul, VY Londhe, Pongamia pinnata seed extract‐mediated green synthesis of silver nanoparticles: Preparation, formulation and evaluation of bactericidal and wound healing potential, Applied Organometallic Chemistry 33 (3), e4624, 2019 (impact factor 3.259),
  • Vaishali Y. Londhe, Rucha Shirsat, Formulation and Characterization of Fast-Dissolving Sublingual Film of Iloperidone Using Box–Behnken Design for Enhancement of Oral Bioavailability, AAPS PharmSciTech, April 2018 Volume 19 Number 3, Pages 1392-1400  (impact factor 2.451)
  • Vaishali Y. Londhe, Aishwarya B. Deshmane, Sarita R. Singh, Yogesh A. Kulkarni, Lurasidone-b-cyclodextrin complexes: Physicochemical characterization and comparison of their antidepressant, antipsychotic activities against that of self microemusifying formulation, Journal of Molecular Structure, Volume 1157, 5 April 2018, Pages 395–400 (impact factor 1.753)
  • Atul Sherje and Vaishali Londhe, Development and Evaluation of pH-Responsive Cyclodextrin-Based in situ Gel of Paliperidone for Intranasal Delivery, AAPS Pharm Sci Tech January 2018, Volume 19, Issue 1, pp 384–394 (impact factor 2.451)

Recent Publications  

  • Vaishali Londhe, Pragya Sharma, Unfolding the future: Self-controlled catalytic nanomotor in healthcare system, Material Science and Engineering:C, Volume 117, December 2020, 111330 (impact factor 5.88)
  • Prasad Pofali, Adrita Mondal and Vaishali Londhe, Exosome as a Natural Gene Delivery Vector for Cancer Treatment, Current Cancer Drug Targets, Vol. 20, No. 11, 2020. (Impact factor 2.72, ISSN:1568-0096)
  • Pooja R. Bakshi, Vaishali Y. Londhe, Widespread applications of host-guest interactive cyclodextrin functionalized polymer nanocomposites: Its meta-analysis and review, Carbohydrate Polymer, Volume 242, 15 August 2020, 116430 (Impact factor 7.182)
  • Vaishali Y. Londhe & Varada Date (2020) Personalized neoantigen vaccines: a glimmer of hope for glioblastoma, Expert Review of Vaccines, 19:5, 407-417, DOI: 10.1080/14760584.2020.1750376 (Impact Factor : 4.531)
  • Kulkarni Shailesh, Londhe Vaishali, Review on: Alternatives to large dosage forms for ease of swallowing, Journal of Drug Delivery Science and Technology 57 June (2020) 101712 (Impact factor 2.606)
  • Saloni Khogata, Jahanvi Patel, Kalyani Barve, Vaishali Londhe, Herbal nano-formulations for topical delivery, Volume 20, April 2020, 100300 (Impact factor 1.554)
  • Vaishali Londhe, Madhura Rajadhyaksha, Opportunities and obstacles for microsampling techniques in bioanalysis: Special focus on DBS and VAMS, Journal of Pharmaceutical and Biomedical analysis, Volume 182, 15 April 2020, 113102 (Impact factor 2.983)
  • Khushwant S. Yadav, Sushmita Sharma, Vaishali Y. Londhe, Bio-tactics for neuroprotection of retinal ganglion cells in the treatment of glaucoma, Life Sciences, Volume 24315 February 2020, 117303 (impact factor 3.448)
  • V Londhe, M Rajadhyaksha, Review of Recommendations for Bioanalytical Method Validation: Chromatographic Assays and Ligand Binding Assays, Chromatographia 82 (2), 523-535, 2019 (impact factor 1.401)
  • VY Londhe, B Bhasin, Artificial intelligence and its potential in oncology, Drug discovery today, 2018(impact factor 6.369)
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