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Dr. Kapil Juvale

Dr. Kapil Juvale

Assistant Professor

Specialization :
Medicinal Chemistry
M. Pharm., Ph.D.

E mail :kapil.juvale@nmims.edu

Phone :022-42332000 (Extn- 2028)

Experience : 8.6 years (Research: 2.6 years, Academics: 6 years)

He has obtained PhD in Pharmaceutical (medicinal) Chemistry from the University of Bonn, Germany in 2013. While pursuing his PhD he also worked as a research and teaching assistant from Oct. 2009-Feb. 2013. After completion of his PhD, he continued working in the same lab at the University of Bonn as a postdoctoral researcher. After returning to India, from Aug. 2014-July-2016 he worked as a postdoctoral fellow at the Indian Institute of Technology Gandhinagar. At the SPP School of Pharmacy & Technology Management, he is working as an Assistant Professor of Pharmaceutical Chemistry.

Interest areas:

  • Design and synthesis of small molecule modulators as anticancer agents
  • ABC transporters involved in MDR in cancer
  • Study of bacterial proteins as potential antibacterial targets
  • Biochemical evaluation of small molecules

Research

  • Publications – 19 (International- 19, National- 0)
  • Patents- 1 (Granted)
  • Presentations- 13 (International- 8, National- 5)
  • Research Grants: 03

oGovernment funded projects: 01

Ongoing: Study of monocarboxylate transporters as potential targets to exploit hypoxia in cancer: design, synthesis and evaluation of MCT1 and MCT4 inhibitors.
Funding agency: DST-SERB, Total Outlay: ₹ 47,82,604/-

oUniversity Seed Grant: 01

Ongoing: Development of small molecule inhibitors of bacterial IMP dehydrogenase as potential therapeutics for infectious diseases. Total Outlay: ₹ 1,00,000/-

oIndustry Projects: 01

Ongoing: Lead Optimisation Consortium India project involving development of potential drug candidates for Leishmaniasis sponsored by Drugs for Neglected Disease initiative (DNDi), Geneva, Switzerland. Total Outlay: 15,12,500/-

Conferences/Workshops/Seminars attended- 29

Academic activities

He has guided 06 M. Pharm. students for their research projects and is currently guiding 05 M. Pharm. Students.

Two candidate is registered for PhD under his supervision.

Awards

  • Teaching excellence award from SVKM’s NMIMS (2019).
  • Indian National Science Academy (INSA) Visiting Scientist Programme 2018-19 Award (2019).
  • Postdoctoral fellowship from IIT Gandhinagar, India (2014-2016).
  • Full fellowship (€ 850) to attend ‘4th FEBS special meeting, ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases’, Innsbruck, Austria. (2012).
  • Travel grant to attend ‘4th SFB-symposium, Transmembrane transporters in health and disease’, Vienna, Austria. (2011).
  • German academic exchange service (DAAD) fellowship for PhD at the University of Bonn, Germany (2009-2013).
  • Fellowship for Master of Pharmacy from AICTE, India (2005-2007).

Professional Memberships

·Association of Pharmaceutical Teachers of India (APTI) – Life Membership (MA/LM-893)

·Registered Pharmacist at Maharashtra State Pharmacy Council.

Recent Publications

  • Puri, S.; Juvale, K.* Monocarboxylate transporter 1 and 4 inhibitors as potential therapeutics for treating solid tumours: A review with structure-activity relationship insights. J. Med. Chem. 2020, 199, 112393. [I.F. 5.572]
  • Hegde, N.; Juvale, K.*; Prabhakar, B.* p-Toluenesulfonyl chloride catalysed facile synthesis of O-benzyl-L-amino acids and their in vitro Int. J. Pept. Res. Ther. 2020, 10.1007/s10989-019-09998-x. [I.F. 1.500]
  • Hegde, N.; Juvale, K.*; Prabhakar, B.* Synthesis and In Vitro Evaluation of Inherent Properties of L-Glutamic Acid Based Dendritic Lipopeptide Oligomers. Pharm. Innov. doi.org/10.1007/s12247-020-09493-7. [I.F. 1.692]
  • Hegde, N.; Juvale, K.*; Prabhakar, B.* Formulation and Optimization of Gefitinib-loaded Nanosuspension Prepared Using A Newly Developed Dendritic Lipopeptide Oligomer Material. Pap, 2020, doi.org/ 10.1007/s11696-020-01453-2. [I.F. 1.680]
  • Juvale, K.; Purushothaman G.; Singh; V.; Shaik, A.; Ravi, S.; Thiruvenkatam, V.; Kirubakaran, S. Identification of selective inhibitors of Helicobacter pylori IMPDH as a targeted therapy for the infection. Scientific Reports 2019, 9:190. [I.F. 3.998]
  • Juvale, K.; Shaik, A.; Kirubakaran, S. Inhibitors of inosine 5′-monophosphate dehydrogenase as emerging new generation antimicrobial agents. MedChemComm. 2019,10, 1290-1301. [I.F. 2.394]
  • Silbermann, K.; Shah, C.; Sahu, N.U.; Juvale, K.; Schmitt S.M.; Kharkar, P.S.;
    Wiese, M. Novel chalcone and flavone derivatives as selective and dual inhibitors of the transport proteins ABCB1 and ABCG2. J. Med. Chem. 2019, 164, 193-213. [I.F. 5.572]
  • Jangra, S.; Purushothaman, G.; Juvale, K.; Ravi, S.; Menon, A.; Kirubakaran, S. Synthesis and in vitro enzymatic studies of new 3-aryldiazenyl indoles as promising Helicobacter pylori IMPDH inhibitors. Curr. Top. Med. Chem. 2019, 19(5), 376-382 [I.F. 3.218].
  • Fernandes, C.; Prabhu, P.; Juvale, K.; Suares, D.; Mayur YC. Cancer cell fusion: a potential target to tackle drug-resistant and metastatic cancer cells, Drug Discov. Today, 2019, 24, 9, 2019, 1836. [I.F. 7.321]                 (*All authors contributed equally)
  • Shah, C.; Purushothaman, G.; Thiruvenkatam, V.; Kirubakaran, S.; Juvale, K.;
    Kharkar, P. Design, synthesis and biological evaluation of Helicobacter pylori inosine 5´-monophosphate dehydrogenase (HpIMPDH) inhibitors. Further optimization of selectivity towards HpIMPDH over human IMPDH2. Bioorg. Chem. 2019, 87, 753-764. [I.F. 4.831]
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