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Dr. Kapil Juvale

Dr. Kapil Juvale

Assistant Professor

Specialization :
Medicinal Chemistry
M. Pharm., Ph.D.

E mail :kapil.juvale@nmims.edu

Phone :022-42332000 (Extn- 2028)

Experience : 8.6 years (Research: 2.6 years, Academics: 6 years)

He has obtained PhD in Pharmaceutical (medicinal) Chemistry from the University of Bonn, Germany in 2013. While pursuing his PhD he also worked as a research and teaching assistant from Oct. 2009-Feb. 2013. After completion of his PhD, he continued working in the same lab at the University of Bonn as a postdoctoral researcher. After returning to India, from Aug. 2014-July-2016 he worked as a postdoctoral fellow at the Indian Institute of Technology Gandhinagar. At the SPP School of Pharmacy & Technology Management, he is working as an Assistant Professor of Pharmaceutical Chemistry.

Interest areas:

  • Design and synthesis of small molecule modulators as anticancer agents
  • ABC transporters involved in MDR in cancer
  • Study of bacterial proteins as potential antibacterial targets
  • Biochemical evaluation of small molecules


  • Publications – 19 (International- 19, National- 0)
  • Patents- 1 (Granted)
  • Presentations- 13 (International- 8, National- 5)
  • Research Grants: 03

oGovernment funded projects: 01

Ongoing: Study of monocarboxylate transporters as potential targets to exploit hypoxia in cancer: design, synthesis and evaluation of MCT1 and MCT4 inhibitors.
Funding agency: DST-SERB, Total Outlay: ₹ 47,82,604/-

oUniversity Seed Grant: 01

Ongoing: Development of small molecule inhibitors of bacterial IMP dehydrogenase as potential therapeutics for infectious diseases. Total Outlay: ₹ 1,00,000/-

oIndustry Projects: 01

Ongoing: Lead Optimisation Consortium India project involving development of potential drug candidates for Leishmaniasis sponsored by Drugs for Neglected Disease initiative (DNDi), Geneva, Switzerland. Total Outlay: 15,12,500/-

Conferences/Workshops/Seminars attended- 29

Academic activities

He has guided 06 M. Pharm. students for their research projects and is currently guiding 05 M. Pharm. Students.

Two candidate is registered for PhD under his supervision.


  • Teaching excellence award from SVKM’s NMIMS (2019).
  • Indian National Science Academy (INSA) Visiting Scientist Programme 2018-19 Award (2019).
  • Postdoctoral fellowship from IIT Gandhinagar, India (2014-2016).
  • Full fellowship (€ 850) to attend ‘4th FEBS special meeting, ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases’, Innsbruck, Austria. (2012).
  • Travel grant to attend ‘4th SFB-symposium, Transmembrane transporters in health and disease’, Vienna, Austria. (2011).
  • German academic exchange service (DAAD) fellowship for PhD at the University of Bonn, Germany (2009-2013).
  • Fellowship for Master of Pharmacy from AICTE, India (2005-2007).

Professional Memberships

·Association of Pharmaceutical Teachers of India (APTI) – Life Membership (MA/LM-893)

·Registered Pharmacist at Maharashtra State Pharmacy Council.

Recent Publications

  • Puri, S.; Juvale, K.* Monocarboxylate transporter 1 and 4 inhibitors as potential therapeutics for treating solid tumours: A review with structure-activity relationship insights. J. Med. Chem. 2020, 199, 112393. [I.F. 5.572]
  • Hegde, N.; Juvale, K.*; Prabhakar, B.* p-Toluenesulfonyl chloride catalysed facile synthesis of O-benzyl-L-amino acids and their in vitro Int. J. Pept. Res. Ther. 2020, 10.1007/s10989-019-09998-x. [I.F. 1.500]
  • Hegde, N.; Juvale, K.*; Prabhakar, B.* Synthesis and In Vitro Evaluation of Inherent Properties of L-Glutamic Acid Based Dendritic Lipopeptide Oligomers. Pharm. Innov. doi.org/10.1007/s12247-020-09493-7. [I.F. 1.692]
  • Hegde, N.; Juvale, K.*; Prabhakar, B.* Formulation and Optimization of Gefitinib-loaded Nanosuspension Prepared Using A Newly Developed Dendritic Lipopeptide Oligomer Material. Pap, 2020, doi.org/ 10.1007/s11696-020-01453-2. [I.F. 1.680]
  • Juvale, K.; Purushothaman G.; Singh; V.; Shaik, A.; Ravi, S.; Thiruvenkatam, V.; Kirubakaran, S. Identification of selective inhibitors of Helicobacter pylori IMPDH as a targeted therapy for the infection. Scientific Reports 2019, 9:190. [I.F. 3.998]
  • Juvale, K.; Shaik, A.; Kirubakaran, S. Inhibitors of inosine 5′-monophosphate dehydrogenase as emerging new generation antimicrobial agents. MedChemComm. 2019,10, 1290-1301. [I.F. 2.394]
  • Silbermann, K.; Shah, C.; Sahu, N.U.; Juvale, K.; Schmitt S.M.; Kharkar, P.S.;
    Wiese, M. Novel chalcone and flavone derivatives as selective and dual inhibitors of the transport proteins ABCB1 and ABCG2. J. Med. Chem. 2019, 164, 193-213. [I.F. 5.572]
  • Jangra, S.; Purushothaman, G.; Juvale, K.; Ravi, S.; Menon, A.; Kirubakaran, S. Synthesis and in vitro enzymatic studies of new 3-aryldiazenyl indoles as promising Helicobacter pylori IMPDH inhibitors. Curr. Top. Med. Chem. 2019, 19(5), 376-382 [I.F. 3.218].
  • Fernandes, C.; Prabhu, P.; Juvale, K.; Suares, D.; Mayur YC. Cancer cell fusion: a potential target to tackle drug-resistant and metastatic cancer cells, Drug Discov. Today, 2019, 24, 9, 2019, 1836. [I.F. 7.321]                 (*All authors contributed equally)
  • Shah, C.; Purushothaman, G.; Thiruvenkatam, V.; Kirubakaran, S.; Juvale, K.;
    Kharkar, P. Design, synthesis and biological evaluation of Helicobacter pylori inosine 5´-monophosphate dehydrogenase (HpIMPDH) inhibitors. Further optimization of selectivity towards HpIMPDH over human IMPDH2. Bioorg. Chem. 2019, 87, 753-764. [I.F. 4.831]
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