Pratigya Tripathi

Qualification             : M. Pharm., Ph.D. (IIT-BHU).                                                

Specialization           : Pharmacology

E mail                          : pratigya.tripathi@nmims.edu

Phone                          : 022-42332000 (2093)

Experience                 : 9 years (Research– 7.5 years, Academics-1.5 years)

Interest areas:

• Drug-discovery and development
• Pharmacology & Toxicology
• Neuroscience
• Cellular & molecular mechanisms driving Alzheimer’s and Parkinson’s Diseases
• Toxicological evaluation of new chemical entity (NEC)
• Mitochondrial and lysosomal targeted medicines
• 6-hydroxydopamine, MPTP, LPS, rotenone, Amyloid beta, scopolamine, and nootropic pre-clinical modeling for neurodegenerative diseases
• Oligomeric proteins and their role in Alzheimer’s and Parkinson’s Diseases
• Neuro-inflammatory mechanism, oxidative-Antioxidant defense system, and their roles in neurodegenerations
• In-vitro screening of novel hits for Alzheimer’s and Parkinson’s Diseases
• Homology modeling, In-silico virtual screening, molecular docking and molecular dynamics simulations for novel hits.

Research:  Publications – Total number (International- 4, National-   0)

• Presentations- Total number (International- 2, National-  1)
• Government funded projects – 2
  • Completed – 1. Novel chaperones for experimental model of Parkinson's disease, Indian council of medical Research, 15.5 Lac)

Conferences/Workshops/Seminars attended- Total number -6

Academic activities

She has guided three M. Pharm students for their research projects.

Awards

• Senior Research fellow -Indian Council of Medical Research (ICMR-SRF)
• Junior Research fellow- Indian institute of Technology, Banaras Hindu University (JRF-IIT (BHU), Varanasi.
• Qualified Graduate Pharmacy aptitude test

Professional Memberships; Pharmacy council of India (Registered)

Recent Publications

1. P. Tripathi, A. Ganeshpurkar, S.K. Singh, S. Krishnamurthy, Identification of novel glucocerebrosidase chaperone for potential treatment of Parkinson's disease: An approach using in silico virtual screening, molecular docking and molecular dynamics, and in vitro studies, Int. J. Biolog. Macromol. 228(2023) 453-466. DOI:10.1016/j.ijbiomac.2022.12.217. Impact factor: 8.03
2. P. Tripathi, A. Ganeshpurkar, S.K. Singh, S. Krishnamurthy, Generation of wild-type rat Glucocerebrosidase homology modeling: Identification of putative interactions site and mechanism for chaperone using combined in-silico and in-vitro studies, Bioorg. Chem. 126(2022), 105871. DOI: 10.1016/j.bioorg.2022.105871. Impact factor: 5.4
3. A. Ganeshpurkar, R. Singh, P. Tripathi, Q. Alam, S. Krishnamurthy, A. Kumar, S.K. Singh, Effect of sulfonamide derivatives of phenylglycine on scopolamine-induced amnesia in rats" Ibrain, 9(2023) 13-31. DOI: doi.org/10.1002/ibra.12092.