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Dr. Yogesh Anant Kulkarni

Dr. Yogesh Anant Kulkarni

Associate Professor, Associate Dean, Section Head, Pharmacognosy

Specialization

Pharmacognosy, Pharmacology
M. Pharm., Ph.D.

Email Id

yogesh.kulkarni@nmims.edu

Phone No.

+91-022-42332000 (Extn- 2038)

Experience

15.8 years

Interest areas: 

  • Phytopharmacology focusing on diabetes, diabetic complications, inflammation and nociception.
  • Toxicity of natural products
  • Standardization of natural products
  • Herbal formulations and cosmetics

Research

· Publications – 80 (International- 71, National- 09)

· Books- 09

· Book Chapters- 25

· Patent- 01

· Presentations- 74 (International- 53, National-21)

Research grants – 21 (Government+ University+ Industry)

Government funded projects – Total 04

Completed- 02

1."Effect of B. varegata (Caesalpiniaceae): a phytomedicine in diabetes and its complications” funded by Department of Science & Technology (DST), Govt. of India, Rs. 35 lakhs. (Principal Investigator).

2. "Development of Model for Non Alcoholic Fatty Liver Disease Based on Ayurvedic Principles” funded by Department of AYUSH, Govt. of India. Rs. 5 lakhs. (Co-Investigator).

Ongoing-02

1."Preclinical Studies on Triphala for its Possible Effects in Treatment of Microvascular Complications of Diabetes” funded by Ministry of AYUSH, Govt. of India. Rs. 36.64 lakhs. (Principal Investigator).

2."Development of Novel formulation for minimally invasive or non-invasive ocular delivery of Anti-VEGF macromolecule for retinoblastoma” funded by Science & Engineering Research Board (SERB), Govt. of India. Rs. 29.35 lakhs. (Co- Investigator)

University funded project- Total-01

Completed-01

"Targeting TGF β Pathway with Combination Of Drugs for Management of Diabetic Nephropathy: A Serious Complication of Diabetes” funded by SVKM’s NMIMS (Deemed to be University), Mumbai. Rs.52000/- (Principal Investigator).

Industry Research Projects -Total 16

Completed- 14

1. To study cardioprotective effect of herbomineral formulations in experimental animals.

2. Standardisation of SP-Max formulation.

3. Dissolution study of Adipomimetin in Sabouraud’s Chloramphenicol medium

4. Acute toxicity study of herbomineral formulation.

5. Effect of herbal formulation on selective reproductive hormones in experimental animals.

6. SDS Page profiling of heat stable protein fractions from plants.
7.Characterization of heat stable proteins fractions from plants by SDS Page profiling and by their sensitivity against microorganism.

8. Effect of herbal formulation on hormone level in azoospermia.
9. Pharmacokinetic profiling of semisynthetic molecule.

10. Pharmacological evaluation of herbal formulation for treatment of azoospermia.

11. To study effect of long term treatment of herbal drug in animal model of chronic renal failure.
12. Evaluation of herbal drug against chronic renal failure in rats.
13. Memory enhancing activity of plant extracts in rat model.
14.Evaluation of some actives & polyherbal formulations for hair growth promoting activity (Pilot Study).

Ongoing- 02

  1. To study effect of herbomineral formulations in animal model of type 2 diabetes.
  2. Estimation of transforming growth factor beta in biological samples.

Conferences/Workshops/Seminars attended- 66

Academic activities

He has guided 42 M. Pharm. students for their research projects.

Three students have successfully completed PhD under his guidance.

Five candidates are registered for PhD under his supervision.

RECENT PUBLICATIONS

1. Ankit P. Laddha, Yogesh A. Kulkarni (2021). Daidzein ameliorates diabetic retinopathy inexperimental animals. Life Science. 265, 118779.(Impact factor- 3.647) DOI: https://doi.org/10.1016/j.lfs.2020.118779.

2. Yogesh A. Kulkarni, Sachin V. Suryavanshi (2021). Combination of naringenin and lisinopril ameliorates nephropathy in Type-1 diabetic rats. Endocrine Metabolic & Immune Disorders-Drug Targets. 21: 173-182. (Impact factor- 1.973) DOI: https://doi.org/10.2174/1871530320666200516163919

3. Kaveri M. Adki, S. Murugesan, Yogesh A. Kulkarni(2020). In Silico and In Vivo Toxicological Evaluation of Paeonol. Chemistry & Biodiversity. 17, e2000422. (Impact factor- 2.039)

DOI: https://doi.org/10.1002/cbdv.202000422

4. Kaveri M Adki, Yogesh A Kulkarni. Potential Biomarkers in Diabetic Retinopathy (2020). Current Diabetes Reviews ;16(9):971-983.

DOI: https://doi.org/10.2174/1573399816666200217092022

5. Sachin V. Suryavanshi, Mayuresh S. Garud, Kalyani Barve, Addepalli V., Sachin V. Utpat, Yogesh A. Kulkarni. (2020) Triphala Ameliorates Nephropathy via Inhibition of TGF-β1 and Oxidative Stress in Diabetic Rats. Pharmacology.;105(11-12):681-691. (Impact factor- 1.6) DOI: https://doi.org/10.1159/000508238.

6. Niharika Shiva, Nisha Sharma, Yogesh A. Kulkarni,Shrikant R. Mulay, Anil Bhanudas Gaikwad (2020). Renal ischemia/reperfusion injury: An insight on in vitro and in vivo models. Life Sciences.256:117860. (Impact factor- 3.647)

DOI: https://doi.org/10.1016/j.lfs.2020.117860

Book Chapters

1. Adki K.M., Kulkarni Y.A. (2021). Glycosides from Natural Sources in the Treatment of Diabetes Mellitus. In: Structure and Health Effects of Natural Products on Diabetes Mellitus. Springer, Singapore. Pp-81-102.

DOI: https://doi.org/10.1007/978-981-15-8791-7_5

2. Laddha A.P., Kulkarni Y.A. (2021). Nitrogenous Compounds from Plant Origin in Management of Diabetes Mellitus. In: Structure and Health Effects of Natural Products on Diabetes Mellitus. Springer, Singapore.Pp 235-249.

DOI: https://doi.org/10.1007/978-981-15-8791-7_13

3. Laddha A.P., Adki K.M., Oza M.J., Gaikwad A.B., Kulkarni Y.A. (2020). Medicinal Plants from Genus Costus in the Management of Diabetes. In: Phytotherapy in the Management of Diabetes and Hypertension. Volume: 4. Bentham Science Publishers, Singapore. Pp. 100-118.

DOI: https://doi.org/10.2174/9789811480515120040006

4. Agrawal O.D., Kulkarni Y.A. (2020). Management of Diabetes Mellitus by Natural Products: Glucagon-like Peptide 1 Perspective In: Phytotherapy in the Management of Diabetes and Hypertension. Volume: 3. Bentham Science Publishers, Singapore. Pp. 95-126.

DOI: https://doi.org/10.2174/9789811459139120030006

5. Adki K.M., Laddha A.P., Oza M.J., Gaikwad A.B., Kulkarni Y.A. (2020). Medicinal Plants from Genus Costus in the Management of Diabetes. In: Phytotherapy in the Management of Diabetes and Hypertension. Volume: 3. Bentham Science Publishers, Singapore. Pp. 127-165. DOI: https://doi.org/10.2174/9789811459139120030007


 

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