Dr. Chandrakant Bonde

Professor
M. Pharm, Ph.D.

Areas of specialization: Pharmaceutical and Medicinal Chemistry

Additional Qualification: MBA

Experience : 20 Years

Interest areas:

• Design and development of new chemical entities (NCEs) as anti-cancer and Antitubercular agents

• Computer aided drug design

• Stability indicating method development using LC-MS

• Analytical and bio analytical method development of Active Pharmaceutical Ingredients (APIs)

• Impurity synthesis of API

 Awards/ Honors & Recognition

• 2021 : Dr. P.D. Sethi National Award for best research paper
• 2019 : Dr. P.D. Sethi National Award for best research paper
• 2018 : Nominated as BOS- Member Pharm Chemistry, Pune University
• 2017 : Nominates as Secretory IPA-Dhule Local Branch.
• 2015 : Poster Evaluator at Scifinder Sponsored seminar at HRP-Shirpur
• 2014 : Resource Person at AICTE Sponsored FDP at SRTMU Nanded.
• 2013 : Chairperson PG Program at NMIMS University.
• 2013 : Resource person in AICTE sponsored FDP at RCP-Shirpur.
• 2012 : HOD, Pharmaceutical Chemistry, SPTM NMIMS University.
• 2012 : Resource Person at AICTE sponsored Seminar at Govt COP Aurangabad
• 2012 : Resource Person at AICTE sponsored FDP at UDPS Nagpur
• 2011 : BOYSCAST fellow- DST to carry research in St Johns University NYC, USA.
• 2010 : Nominated as BOS- Member Pharm Sciences, NMIMS University
• 2009 : Resource person in SDP at RCP shirpur
• 2008 : Nominated as executive council member by APTI- Maharashtra state Branch-India
• 2008 : Nominated as BOS- Member Pharm Sciences, NMIMS University
• 2008 : Recognized as PG Teacher by University of Pune
• 2006 : Received Most Cited Research Article award 2003-2006 from Elsevier Ltd, Oxford, UK.
• 1998 : Received Junior Research Fellowship from Haffkine Institute For Training Research and Testing in the year 1998-2001.

Projects /Grants

1. Proposal Title : Design and synthesis of novel HIV capsid Inhibitors

   Agency : AICTE (RPS)

   Role on the Project : Principle Investigator

   Total award : Rs. 17.40 Lakhs

2.  Proposal Title : Modelling for New Drug Development.

   Agency : DST (Fellowship)

   Role on the Project : Principle Investigator

   Total award : Rs. 8.23 Lakhs

3. Proposal Title : Identification of Novel Scaffold and elaboration of tricyclic DPP-IV Inhibitors with Molecular Modelling studies

   Agency : NMIMS University

   Role on the Project : Principle Investigator

   Total award : Rs. 1.0 Lakhs 

4. Proposal Title : Design and synthesis of novel DprE1 inhibitors

   Agency : NMIMS University

   Role on the Project : Principle Investigator

   Total award : Rs. 0.8 Lakhs

5. Proposal Title : Quality Control of Stents

   Agency : MIV Therapeutics

   Role on the Project : Principle Investigator

   Total award : Rs. 1.5 Lakhs

6. Proposal Title : Toxicity study of Opthalmic preparation AJ-1

   Agency : Ajanta Pharma Ltd, Mumbai

   Role on the Project : Co-Principle Investigator

   Total award : Rs. 0.76 Lakhs

7. Proposal Title : STTP on Medicinal Chemistry in Drug Discovery

   Agency : AICTE

   Role on the Project : Project Co-ordinator

   Total award : Rs. 3.20 Lakhs

8. Proposal Title : Travel Grant

   Agency : AICTE

   Total award : Rs. 1.14 Lakhs

Patents: 

• Balaramnavar VM, Bonde CG, Bonde SC, Bhole RP, Khurshid A, et al  "Discovery Of Imatinib A Drug For Treating Coronaviridae Family Of Virus” Application No.20211100283, Publication Date : 12/02/2021 

Number of Publications: 61

Recent Publications: (Last three years)

1. Gawad, J., & Bonde, C.G. Design, synthesis and biological evaluation of novel 6-(trifluoromethyl)-N-(4-oxothiazolidin-3-yl) quinazoline-2-carboxamide derivatives as a potential DprE1 inhibitors Journal of Molecular Structure, (2020) 1217, 128394.
2. Bhole, R., Sarode, V., & Bonde, C. (2020). Understanding and implementing alternative solutions to address the COVID-19 pandemic in the sense of public health emergencies Eur Rev Med Pharmacol Sci, 24(13),(2020)7485–7493.

3. Agrawal, R., Belemkar, S., & Bonde, C. (2020). Supercritical fluid chromatography versus liquid chromatography for the enantiomeric separation of itraconazole Microchemical Journal,(2020) 158, 105320.

4. Ritesh Bhole, Khandu Chadar, Yogesh Zambre, Chandrakant Bonde. Development and validation of HPTLC method for estimation of dofetilide in pharmaceutical dosage form and determination of its degradation profile by MS-MS method. (2020) Istanbul J Pharm, 50(2), 71–78.

5. Ritesh Bhole, Chandrakant Bonde, Preeti Kadam, Ravindra Wavwale. A Comprehensive Review on Photodynamic Therapy (PDT) and Photothermal Therapy (PTT) for Cancer Treatment, Turkish Journal Of Oncology, (2020)36(1), 629–36.
6. Bhole, R., Jadhav, S., Zambare, Y., Chikhale, R., & Bonde, C. (2020). Vitamin-anticancer drug conjugates: a new era for cancer therapy.Journal of the Faculty of Pharmacy of Istanbul University, (2020) 50(3), 312–323.

7. P. Chaudhari, Vinod G. Ugale, S B. Bari, C.G. Bonde, Saurabh C. Khadse,Pedavenkatagari Narayana Reddy,Exploring Quinazolinones as Anticonvulsants by Molecular Fragmentation Approach: Structural Optimization, Synthesis and Pharmacological Evaluation Studies, ChemistrySelect (2020) 5 (10), 2902-2912

8. R.P. Bhole, V.I. Sarode, C.G .Bonde,Understanding and implementing alternative solutions to address the COVID-19 pandemic in the sense of public health emergencies, Eur Rev Med Pharmacol Sci. ( 2020)24 (13), 7485-7493

9. Ritesh Bhole, Khandu Chandar, Yogesh Zambre, chandrakant Bonde,Development and validation of HPTLC method for estimation of dofetilide in pharmaceutical dosage form and determination of its degradation profile by MS-MS method Istanbul J Pharm(2020)50 (2), 71-78

10. Bhole R, Bonde C, Bonde S, Chikhale R, Wavhale R, "Pharmacophore Model and Atom-Based 3D Quantitative Structure Activity Relationship (QSAR) of Human Immunodeficiency Virus-1 (HIV-1) Capsid Assembly Inhibitors."Journal of Biomolecular Structure and Dynamics (just-accepted) (2020): 1-14.

11. Agrawal R, Sateesh B, Bonde C,. A Stepwise Strategy Employing Automated Screening for Reversed‑Phase Chromatographic Separation of Itraconazole and Its Impurities. Chromatographia , 2019
12. Bonde S, Bonde C, Prabhakar B. Quality by design based development and validation of HPLC method for simultaneous estimation of paclitaxel and vinorelbine tartrate in dual drug loaded liposomes. Microchemical Journal. 2019, 103982
13. Gawad J, Bonde C. Design, synthesis and biological evaluation of some 2-(6-nitrobenzo [d] thiazol-2-ylthio)-N-benzyl-N-(6-nitrobenzo [d] thiazol-2-yl) acetamide derivatives as selective DprE1 Synthetic Communications 49 (20), 2696-2708
    
14. Bhole RP, Naksakhare SR, Bonde CG. A Stability Indicating HPTLC Method for Apremilast and Identification of degradation products using MS/MS. Journal of Pharmaceutical Sciences and Research. 2019, 11(5), 1861-9.
15. Ritesh P. Bhole TZ, Chandrakant G. Bonde, Y.B. Zambare. Identification and Characterization of Degradation Products by Using MS-MS Studies for Developed and Validated Stability Indicating HPTLC Method for Estimation of Nintedanib Esylate in Pharmaceutical Dosage Form. Eurasian Journal of Analytical Chemistry. 2019, 14(2), 60-70.
16. Bonde S, Mavani N, Bonde C. Formulation, Optimization and Evaluation of Organogel for Topical Delivery of Acyclovir. Current drug delivery. 2018, 15(3), 397-405.
17. Gawad J, Bonde C. Current affairs, future perspectives of tuberculosis and antitubercular agents. Indian Journal of Tuberculosis. 2018, 65(1), 15-22.
18. Gawad J, Bonde C. Synthesis, biological evaluation and molecular docking studies of 6-(4-nitrophenoxy)-1 H-imidazo [4, 5-b] pyridine derivatives as novel antitubercular agents: future DprE1 inhibitors. Chemistry Central Journal. 2018, 12(1), 138.
19. Gawad J, Chandrakant B. Decaprenyl-phosphoryl-ribose 2′-epimerase (DprE1): challenging target for antitubercular drug discovery. BMC Chemistry . 2018, 12(72), 1-12.
20. Ritesh Bhole CB, Pooja Biradar. Development and Validation of Stability Indicating HPTLC Method for Estimation of Dasatinib and Characterization of Degradation Products by Using Mass Spectroscopy. Eurasian Journal of Analytical Chemistry. 2018, 13(4), 1-10.
21. Ritesh P. Bhole YBZ, C. G. Bonde. Effective potential studies for some new hybrid molecules for their activity against prostate cancer. Ars Pharmaceutica. 2018, 59(3), 133-44.
22. Roopali Agrawal SB, Chandrakant Bonde. Orthogonal Separations in Reversed-Phase Chromatography. Chromatographia. 2018.
23. Bonde C, Bonde S, Gawad JK. Application of Quality by Design for Development and Validation of RP-HPLC Method for Lercanidipine Hydrochloride. Asian Journal of Chemistry. 2017, 29(12).
24. Gawad J, Bonde C. Artificial intelligence: future of medicine and healthcare. Biochem Ind J. 2017, 11(2), 113.
25. Gawad JK, Bonde C. Infrared and Raman Spectroscopy in Diagnosis of Infectious Diseases. Asian Journal of Chemistry. 2017, 29(4), 703.
26. Mhaske A, Gawad J, Bonde C. Nitrogen Fixation by Transition Metals: A Review. Sci Revs Chem Commun. 2017, 7(1), 102.

Professional memberships:

1. Indian Pharmaceutical Association
2. Association of Pharmaceutical teachers of India
3. Indian congress of chemistry and environment
4. Indian society of technical education

Other achievements/ Trainings:

• Attended the AICTE-ISTE sponsored faculty development program for two weeks on the topic "Emerging Trends in Pharmaceutical Technology” at Nagpur College of Pharmacy, Nagpur, Maharashtra, India.

• Attended the NMIMS University sponsored certification program for two weeks on the topic "Business Analytics” at Mukesh Patel Technology Park, SVKMs NMIMS, Shirpur, Maharashtra, India.

• Attended the NMIMS University sponsored certification program for Three days on the topic "Role of faculty in accreditation, Ranking & Quality Education” at SPPSPTM, SVKMs NMIMS, Mumbai, Maharashtra, India.

• Attended the AICTE sponsored faculty development program for two weeks on the topic "Emerging Frontiers in Drug Discovery” at BVP’s Poona College of Pharmacy, Pune, Maharashtra, India.

• Attended Three days Hands-On Training on ‘Biotechnology & Bioinformatics’at Bioera Research & Development Pvt Ltd

• Successfully completed AICTE sponsored faculty development program for four weeks on the topic "Use of ICT in Education for Online and Vlended Learning

• Completed four NMIMS Sponsored workshop University Interschool FDP at NMIMS Mumbai.

• Completed One Week Faculty Development program on "Modernizing Teaching Practices in Pharma Education” at NMIMS Shirpur

• Completed STEM Teachers Training Workshop on Research Based Pedagogical Tool at IIT Gandhinagar.

• Certificate course completed. Teach English Now! Second Language Listening, Speaking, and Pronunciation by Arizona State University on Coursera. Certificate earned at Saturday, October 13, 2018.