Dr. Yogesh Kulkarni

Associate Professor

Qualification              : M. Pharm., Ph.D.

Specialization             : Pharmacognosy, Pharmacology

E mail                         : yogesh.kulkarni@nmims.edu

Phone                         : 022-42332000 (Extn- 2009)

Experience                 : 19 years

Research

• Publications – 128 (International- 119, National- 09)
• Books- 09
• Book Chapters- 38
• Patent- 02
• Presentations- 102 (International- 74, National-28)

Research grants – 32 (Government+ University+ Industry)

Government funded projects – Total 04 (Competed-02, Ongoing-02)

Completed- 03

1. "Preclinical Studies on Triphala for its Possible Effects in Treatment of Microvascular Complications of Diabetes” funded by Ministry of AYUSH, Govt. of India. Rs. 36.64 lakhs. (Principal Investigator).

2. "Effect of varegata (Caesalpiniaceae): a phytomedicine in diabetes and its complications” funded by Department of Science & Technology (DST), Govt. of India, Rs. 35 lakhs. (Principal Investigator).

3. "Development of Model for Non Alcoholic Fatty Liver Disease Based on Ayurvedic Principles” funded by Department of AYUSH, Govt. of India. Rs. 5 lakhs. (Co-Investigator).

Ongoing-02

4. "EGFR-targeting PANAM dendrimer-based conjugates for prolonged therapeutic efficacy in ovarian cancer” funded by AICTE, Govt. of India. Rs.17.35 lakhs (Co- Investigator)
5. "Development of Novel formulation for minimally invasive or non-invasive ocular delivery of Anti-VEGF macromolecule for retinoblastoma” funded by Science & Engineering Research Board (SERB), Govt. of India. Rs. 29.35 lakhs.  (Co- Investigator)

University funded project- Total-02

Completed-01

"Targeting TGF β Pathway with Combination Of Drugs for Management of Diabetic Nephropathy: A Serious Complication of Diabetes” funded by SVKM’s NMIMS (Deemed to be University), Mumbai. Rs.52,000/- (Principal Investigator).

Ongoing-01

"Pharmacological Evaluation of Triphala Churna in Dehydroepiandrosterone Induced Polycystic Ovarian Syndrome in Rats” funded by SVKM’s NMIMS (Deemed to be University), Mumbai. Rs.2 lakhs (Principal Investigator).

Industry Research Projects -  Total 31 (Completed-21, Ongoing-10)

Completed- 21

1. In-Vitro antioxidant activity and In-Vivo Studies on a pharmaceutical composition for Diabetic Nephropathy. (Co-PI)
2. Estimation of transforming growth factor beta in biological samples.
3. Pharmacological evaluation of herbal products for treatment of anxiety.
4. Estimation of neurotransmitters in brain samples of experimental animals.
5. Evaluation of spermicidal activity of HOCl: an in vitro study.
6. HPLC analysis of selected plant extracts.
7. To study effect of herbomineral formulations in animal model of type 2 diabetes.
8. Standardisation of  SP-Max formulation.
9. Evaluation of herbal drug against chronic renal failure in rats.
10. To study effect of long term treatment of herbal drug in animal model of chronic renal failure.
11. Pharmacological evaluation of herbal formulation for treatment of azoospermia.
12. Pharmacokinetic profiling of semisynthetic molecule.
13. Effect of herbal formulation on hormone level in azoospermia.
14. Characterization of heat stable proteins fractions from plants by SDS Page profiling and by their sensitivity against microorganism.
15. SDS Page profiling of heat stable protein fractions from plants.
16. Effect of herbal formulation on selective reproductive hormones in experimental animals
17. Acute toxicity study of herbomineral formulation
18. To study cardioprotective effect of herbomineral formulations in experimental animals.
19. Dissolution study of Adipomimetin in Sabouraud’s Chloramphenicol medium.
20. Evaluation of some actives & polyherbal formulations for hair growth promoting activity (Pilot Study). (Co-PI)
21. Memory enhancing activity of plant extracts in rat model.(Co-PI)

 

Ongoing- 10

1. Phytochemical investigations of selected crude drugs and Ayurvedic product.
2. Exploring potential of herbomineral formulation in diabetic complications
3. Preclinical study of herbal formulation (PCOSnil) for polycystic ovarian syndrome.
4. Evaluation of combination of herbal formulation (PCOSnil) and selective drugs in animal model of polycystic ovarian syndrome.
5. To study natural killer cells activity in biological samples.
6. Standardisation of herbal formulation.
7. Preclinical studies on a nutraceutical product for management of Alzheimer’s disease.
8. Pharmacokinetic study of oral formulations.
9. Effect of herbal formulation on antimullerian hormone and some biochemical parameters.
10. Acute and repeated dose toxicity study of polyherbal capsule formulation

Conferences/Workshops/Seminars attended- 71

Academic activities

He has guided 40+ M. Pharm. students for their research projects.

08 students have successfully completed PhD under his guidance.

Five candidates are registered for PhD under his supervision.

RECENT PUBLICATIONS

1. Alok D. Singh, Mukesh B. Chawda, Yogesh A. Kulkarni (2024). Cardioprotective Effects of ‘Vasant Kusumakar Rasa,’ a Herbo‑metallic Formulation, in Type 2 Diabetic Cardiomyopathy in Rats. Cardiovascular Toxicology. 24:942–954. (Impact factor-3.4) DOI: https://doi.org/10.1007/s12012-024-09891-0

2. Mayuresh S. Garud, Ankit P. Laddha, Yogesh A. Kulkarni (2024). Potential of Bauhinia variegata leaves in the management of diabetic nephropathy. Pharmacological Research - Natural Products. 4, 100072. DOI: https://doi.org/10.1016/j.prenap.2024.100072

3. Shreya Adangale, Alok D. Singh, Yogesh A. Kulkarni, Sarika Wairkar (2024). Brain-targeted nasal chrysin microemulsion for reducing oxidative stress in Parkinson's disease: Pharmacodynamic, biochemical evaluation and brain distribution studies. Journal of Drug Delivery Science and Technology. 97, August 2024, 105756. (Impact Factor-5) DOI: https://doi.org/10.1016/j.jddst.2024.105756

4. Laddha AP and Kulkarni YA (2024), Daidzein ameliorates peripheral neuropathy in Sprague Dawley rats. Front. Pharmacol. 15:1385419. (Impact factor: 4.4) DOI: https://doi.org/10.3389/fphar.2024.1385419

5. Komaldeep Kaur , Yogesh A. Kulkarni , Sarika Wairkar (2024). Exploring the potential of quercetin in Alzheimer’s Disease: Pharmacodynamics, Pharmacokinetics, and Nanodelivery systems. Brain Research. 1834 (2024) 148905. (Impact factor: 2.9) DOI: https://doi.org/10.1016/j.brainres.2024.148905

6. Alok Singh, Mukesh B. Chawda and Yogesh A. Kulkarni (2024). Pharmacological Evaluation of Vasant Kusumakar Rasa in High Fat Diet and Streptozotocin-Induced Diabetic Retinopathy in Rats. Journal of Pharmacology and Experimental Therapeutics, 389 (S3) 402. (Impact factor-3.5)  DOI: https://doi.org/10.1124/jpet.402.914200

7. Vishwadeep Shelke, , Ajinath Kale, Yogesh A. Kulkarni, Anil Bhanudas Gaikwad (2024). Phloretin: a comprehensive review of its potential against diabetes and associated complications. Journal of Pharmacy and Pharmacology, 76, 201–212. (Impact Factor: 3.3) DOI: https://doi.org/10.1093/jpp/rgae010

8. Sachin V Suryavanshi, Yogesh A. Kulkarni (2024). Abrogation of cardiomyopathy in diabetic rats by escin - possible role of NF-κβ and MCP-1. Archives of Physiology and Biochemistry. 130 (1), 49-55 (Impact factor-3.00) DOI:  https://doi.org/10.1080/13813455.2021.1963782

9. Mudassir Ansari, Yogesh A. Kulkarni, Kavita Singh (2024). Advanced Technologies of Drug Delivery to the Posterior Eye Segment Targeting Angiogenesis and Ocular Cancer. Critical Reviews in Therapeutic Drug Carrier Systems. 41(1): 85-124 (Impact factor: 2.7).DOI: https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2023045298  

10. Ankit P. Laddha, Shantanu Joshi, Yogesh A. Kulkarni (2024). SP-Max-A herbomineral formulation attenuates busulfan-induced oligospermia in mice by preventing loss of reproductive hormones. Reproductive Toxicology. 108525 (Impact factor: 3.3) DOI: https://doi.org/10.1016/j.reprotox.2023.108525

11. Shraddha I. Khairnar, Yogesh A. Kulkarni, Kavita Singh (2024). Mitigation of cisplatin-induced nephrotoxicity by chelidonic acid in Wistar rats. Journal of Trace Elements in Medicine and Biology 127321. (Impact factor: 3.5) DOI: https://doi.org/10.1016/j.jtemb.2023.127321

12. Shraddha I. Khairnar, Yogesh A. Kulkarni, Kavita Singh (2024). Effects of Acute and Repeated Dose Toxicity Profiling of Chelidonic Acid in Rats: in Silico and in Vivo Evidence. Chemistry & Biodiversity. 20, e202301241 (Impact factor: 2.9) DOI: https://doi.org/10.1002/cbdv.202301241

13. Avinash S. Poojari , Sarika Wairkar , Yogesh A. Kulkarni (2023). Stem cells as a regenerative medicine approach in treatment of microvascular diabetic complications. Tissue and Cell. 85. 102225. (Impact Factor: 2.6) DOI: https://doi.org/10.1016/j.tice.2023.102225

14. Ankit P. Laddha, Yogesh A. Kulkarni (2023). Pharmacokinetics, pharmacodynamics, toxicity, and formulations of daidzein: An important isoflavone. Phytotherapy Research. 37:2578–2604. (Impact factor: 6.388). DOI:  https://doi.org/10.1002/ptr.7852

15. Ojaskumar D. Agrawal and Yogesh A. Kulkarni (2023). Treatment with Terminalia chebula Extract Reduces Insulin Resistance, Hyperglycemia and Improves SIRT1 Expression in Type 2 Diabetic Rats. Life. 13, 1168. (Impact factor: 3.251) DOI: https://doi.org/10.3390/life13051168

16. Jadhav, R.; Kulkarni, Y.A. (2023). The Combination of Baicalein and Memantine Reduces Oxidative Stress and Protects against -amyloid-Induced Alzheimer’s Disease in Rat Model. Antioxidants, 12, 707. (Impact factor- 7.675) DOI: https://doi.org/10.3390/antiox12030707

17. Adki KM, Kulkarni YA. (2023). Biomarkers in diabetic neuropathy. Archives of Physiology Biochemistry. 129, NO. 2, 460–475. (Impact factor- 3.188) DOI: https://doi.org/10.1080/13813455.2020.1837183 .
18. Himanshu Sankrityayan, Pooja Dhileepkumar Rao, Vishwadeep Shelke, Yogesh A. Kulkarni, Shrikant R Mulay, Anil Bhanudas Gaikwad (2023). Endoplasmic Reticulum Stress and Renin-Angiotensin System Crosstalk in Endothelial Dysfunction. Current Molecular Pharmacology. 16 (2), 139-146. (Impact factor- 3.885) DOI https://doi.org/10.2174/1874467215666220301113833

19. Jadhav R and Kulkarni YA (2023), Effects of baicalein with memantine on aluminium chloride-induced neurotoxicity in Wistar rats. Frontiers in Pharmacology. 14:1034620. (Impact factor- 5.988) DOI: https://doi.org/10.3389/fphar.2023.1034620

20. Kopal Agarawal, Yogesh Anant Kulkarni, Sarika Wairkar (2023). Nanoformulations of flavonoids for diabetes and microvascular diabetic complications. Drug Delivery and Translational Research. 13(1):18-36. (Impact factor: 5.671)   DOI: https://doi.org/10.1007/s13346-022-01174-x 

21. Jadhav, Ratnakar, and Yogesh A. Kulkarni. 2023. "Neuroprotective Effect of Quercetin and Memantine against AlCl₃-Induced Neurotoxicity in Albino Wistar Rats" Molecules 28, no. 1: 417. (Impact factor- 4.927) DOI: https://doi.org/10.3390/molecules28010417

22. Fuloria NK, Raheja RK, Shah KH, Oza MJ, Kulkarni YA, Subramaniyan V, Sekar M,Fuloria S (2022). Biological activities of meroterpenoids isolated from different sources. Frontiers in Pharmacology. 13:830103. (Impact factor- 5.988)

Book Chapters

1. Poojari, A.S., Kulkarni, Y.A., Wairkar, S. (2024). Starch-Based Hydrogel in Drug Delivery Applications. In: Jana, S. (eds) Biomaterial-based Hydrogels. Springer, Singapore. DOI: https://doi.org/10.1007/978-981-99-8826-6_5
2. Ojaskumar D. Agrawal, Yogesh A. Kulkarni (2023). Dietary neurotoxins: An overview. In: Diet and Nutrition in Neurological Disorders, Academic Press: Elsevier, USA. Pages 351-364. ISBN- 978-0-323-89834-8 DOI: https://doi.org/10.1016/B978-0-323-89834-8.00037-4

3. Manisha J. Oza, Anil B. Gaikwad, Yogesh A. Kulkarni (2023). Effect of diet and nutrition on neuroinflammation: An overview. In: Diet and Nutrition in Neurological Disorders, Academic Press: Elsevier, USA. Pages 597-611. ISBN- 978-0-323-89834-8 DOI: https://doi.org/10.1016/B978-0-323-89834-8.00030-1

4. Nisha Sharma, Niharika Shiva, Yogesh A. Kulkarni, Anil Bhanudas Gaikwad (2023). Role of histone modifications in the development of acute kidney injury. In: Epigenetics in Organ Specific Disorders, Volume 34 in Translational Epigenetics. Academic Press: Elsevier, USA. Pages 447-464. ISBN- 978-0-12-823931-5 DOI: https://doi.org/10.1016/B978-0-12-823931-5.00016-5

5. Deepa S. Mandlik, Yogesh A. Kulkarni (2022). Drugs from Natural Sources in the Management of Skin Diseases. In: Chemistry inside spices & herbs: research & development, Volume 2    Bentham Science Publishers, Singapore.  Pages-1-70. ISBN: 978-1-68108-950-8 (Print) ISBN: 978-1-68108-949-2 (Online). DOI: https://doi.org/10.2174/9781681089492122020004 

6. Ojaskumar D. Agrawal, Yogesh A. Kulkarni (2022). Phytochemistry and Pharmacology of Terminalia chebula: An Update (2022).Chemistry inside spices & herbs: research & development, Volume 2. Bentham Science Publishers, Singapore. Pages-229-260. ISBN: 978-1-68108-950-8 (Print), ISBN: 978-1-68108-949-2 (Online) DOI: https://doi.org/10.2174/9781681089492122020012

7. Yogesh Kulkarni (2022). "Antidiabetic drugs” In: Textbook of Pharmacology Thieme Medical and Scientific Publishers. ISBN 978-93-90553-15-0
8. Ankit P. Laddha, Yogesh A. Kulkarni. (2022). Vascular Endothelial Growth Factor and Inflammatory Airway Diseases: An Update, Editor(s): Sam M Janes, Encyclopedia of Respiratory Medicine (Second Edition), Academic Press: Elsevier, USA. Pages 401-408.  ISBN 978-0-08-102724-0 DOI: https://doi.org/10.1016/B978-0-08-102723-3.00211-0

9. Ankit P. Laddha, Anil B. Gaikwad, Yogesh A. Kulkarni (2021). Receptors | Structural and Functional Insights of VEGF and Its Receptors, Editor(s): Joseph Jez, Encyclopedia of Biological Chemistry III (Third Edition), Elsevier, Pages 286-293. ISBN 978-0-12-822040-5. DOI: https://doi.org/10.1016/B978-0-12-819460-7.00131-6
10. Malek V., Suryavanshi S.V., Sharma N., Kulkarni Y.A., Mulay S.R., Gaikwad A.B. (2021) Potential of Renin-Angiotensin-Aldosterone System Modulations in Diabetic Kidney Disease: Old Players to New Hope!. In: Reviews of Physiology, Biochemistry and Pharmacology. Springer, Cham. Vol 179, pp 31-71. (Impact factor- 5.545) DOI: https://doi.org/10.1007/112_2020_50 Print ISBN-978-3-030-74288-1,  Online ISBN-978-3-030-74289-8

11. Adki K.M., Kulkarni Y.A. (2021). Glycosides from Natural Sources in the Treatment of Diabetes Mellitus. In: Structure and Health Effects of Natural Products on Diabetes Mellitus. Springer, Singapore. Pp-81-102.DOI: https://doi.org/10.1007/978-981-15-8791-7_5 , Print ISBN 978-981-15-8790-0,  Online ISBN 978-981-15-8791-7

12. Laddha A.P., Kulkarni Y.A. (2021). Nitrogenous Compounds from Plant Origin in Management of Diabetes Mellitus. In: Structure and Health Effects of Natural Products on Diabetes Mellitus. Springer, Singapore. Pp 235-249. Print ISBN 978-981-15-8790-0, Online ISBN 978-981-15-8791-7 DOI: https://doi.org/10.1007/978-981-15-8791-7_13 

13. Laddha A.P., Adki K.M., Oza M.J., Gaikwad A.B., Kulkarni Y.A. (2020). Medicinal Plants from Genus Costus in the Management of Diabetes. In: Phytotherapy in the Management of Diabetes and Hypertension. Volume: 4. Bentham Science Publishers, Singapore. 100-118. eISBN: 978-981-14-8051-5, ISBN: 978-981-14-8049-2, ISSN: 2452-3224 (Print), ISSN: 2452-3232 (Online). DOI: https://doi.org/10.2174/9789811480515120040006

14. Agrawal O.D., Kulkarni Y.A. (2020). Management of Diabetes Mellitus by Natural Products: Glucagon-like Peptide 1 Perspective In: Phytotherapy in the Management of Diabetes and Hypertension. Volume: 3. Bentham Science Publishers, Singapore. 95-126. eISBN: 978-981-14-5913-9, ISBN: 978-981-14-5911-5, ISSN: 2452-3224 (Print), ISSN: 2452-3232 (Online). DOI: https://doi.org/10.2174/9789811459139120030006

15. Adki K.M., Laddha A.P., Oza M.J., Gaikwad A.B., Kulkarni Y.A. (2020). Medicinal Plants from Genus Costus in the Management of Diabetes. In: Phytotherapy in the Management of Diabetes and Hypertension. Volume: 3. Bentham Science Publishers, Singapore. 127-165. eISBN: 978-981-14-5913-9, ISBN: 978-981-14-5911-5, ISSN: 2452-3224 (Print), ISSN: 2452-3232 (Online). DOI: https://doi.org/10.2174/9789811459139120030007 ,

16. Kaveri M. Adki, Ankit P. Laddha, Anil B. Gaikwad, and Yogesh A. Kulkarni (2020). Potential Role of Seeds from India in Diabetes. In: Nuts and Seeds in Health and Disease Prevention. Second Edition. Academic Press: Elsevier, USA. Pp-365-391. ISBN: 978-0-12-818553-7 DOI: https://doi.org/10.1016/B978-0-12-818553-7.00026-7

17. Ankit P. Laddha, Kaveri M. Adki, Anil B. Gaikwad, and Yogesh A. Kulkarni (2020). Beneficial Effects of Nuts From India in Cardiovascular Disorders. In: Nuts and Seeds in Health and Disease Prevention. Second Edition. Academic Press: Elsevier, USA. Pp-453-469. ISBN: 978-0-12-818553-7 DOI: https://doi.org/10.1016/B978-0-12-818553-7.00032-2

18. Manisha J. Oza, Sachin V. Suryavanshi, Mayuresh S. Garud, Sandip T. Auti, Ankit P. Laddha and Yogesh A. Kulkarni. (2019). Molecular Targets of Angiogenesis and Future Potential of Anti-angiogensis Therapy in Multiple Sclerosis. In: Anti-Angiogenesis Drug Discovery and Development. Volume 4. Bentham Science Publishers. Pp-137-161 eISBN: 978-1-68108-397-1; ISBN: 978-1-68108-398-8; ISSN: 2452-3240 (Print); ISSN: 2210-268X (Online) DOI: https://doi.org/10.2174/97816810839711170401 ,

19. Yogesh A. Kulkarni, Mayuresh S. Garud, R. S. Gaud. Insulin Therapy for Diabetes: Current Scenario and Future Perspectives. In: Medicinal Chemistry with Pharmaceutical Product Development. Apple Academic Press Inc., USA. Pp-293-318.Hard ISBN: 9781771887106; E-Book ISBN: 9780429487842  DOI: https://doi.org/10.1201/9780429487842-8

AWARDS/ACHIEVEMENTS

1. Listed in "TOP 2% Scientist in the world”. List published by Standford University & Elsevier. 2021, 2022, 2023 and 2024.
2. Received "Prof. Manjeeth Singh Award” for presentation of research work related to molecular pharmacology at 52^nd Annual Conference of Indian Pharmacological Society.
3. Received "Publons Peer Review Awards 2018” for being placed in top 1% of reviewers in the area of "Pharmacology & Toxicology”.
4. Received Best Research Output Award (Year 2015-2016), SVKM’s NMIMS (Deemed to be University), SPP School of Pharmacy & Technology Management, Mumbai.
5. Received travel grant from Science & Engineering Research Board (SERB), Govt. of India for attending conference Pharmacology 2014 organized by British Pharmacological Society, London, UK.
6. Received Best Faculty Award (Year 2012-2013), SVKM’s NMIMS (Deemed to be University), SPP School of Pharmacy & Technology Management, Mumbai.
7. Received INSPIRE Faculty Award 2012 from Department of Science & Technology (DST), Govt. of India.
8. Selected by the American Biographical Institute for Sir Isaac Newton Scientific Award of Excellence For 2012.
9. Admitted as Fellow of Academy of Sciences for Animal Welfare in 2012.The academy of Sciences for Animal Welfare is working for prevention of cruelty, enhancement of animal health and use of minimum animals for Research & Development. The academy is approved body of Animal Welfare Board which is under Ministry of Environment and Forests, Govt. of India.
10. Listed as Member (Biography) of MARQUIS Who's Who in the World 2012, USA.
11. Received grant from "Department of Science & Technology (DST), of India” under Young Scientist category for attending Experimental Biology 2011 at Washington DC, USA, under "International Travel Support Scheme”.
12. Received travel grant from "All India Council of Technical Education (AICTE)”, New Delhi, India for attending 29th Annual meeting of American College of Toxicology, Tucson, Arizona, USA.